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Kv1.2 Rabbit pAb(bs-16865R)-50

ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-16865R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-16865R
    英文名称Kv1.2 Rabbit pAb
    中文名称电压门控钾通道Kv1.2抗体
    英文别名Akr6a4; BK2; HBK5; HK4; HUKIV; Kca1 2; kcna2; KV1.2; MGC50217; Mk 2; MK2; NGK1; Potassium voltage gated channel shaker related subfamily member 2; Potassium voltage-gated channel subfamily A member 2; RBK2; Voltage gated potassium channel subunit Kv1.2; KCNA2_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse (Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Kv1.2
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量57 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Neurotransmission > Receptors / Channels > Potassium Channels

    亚基Heterotetramer of potassium channel proteins.
    亚细胞定位Membrane; Multi-pass membrane protein
    相似性Belongs to the potassium channel family.
    功能 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Kv1.2 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which K(+) ions may pass in accordance with their electrochemical gradient. Kv1.2 binds PDZ domains of DLG1, DLG2 and DLG4. The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:
    Spinal cord (Mouse) Lysate at 40 ug
    Primary: Anti-Kv1.2 (bs-16865R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 57 kD
    Observed band size: 57 kD
    产品细节图片2
    Sample:
    Cerebellum (Mouse) Lysate at 40 ug
    Primary: Anti-Kv1.2 (bs-16865R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 57 kD
    Observed band size: 57 kD
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Kv1.2) Polyclonal Antibody, Unconjugated (bs-16865R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    产品细节图片4
    P‌‌araformaldehyde-fixed, paraffin embedded (Mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Kv1.2) Polyclonal Antibody, Unconjugated (bs-16865R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    该产品被引用文献

    [IF={{ 7.5 }}] {Xiaomin Yang. et al. Cinnamaldehyde prevents coronary artery spasm by down-regulating the function and expression of voltage-gated Ca2+ channels and Ca2+ -activated Cl- channels in the arterial smooth muscle cells. BIOMED PHARMACOTHER. 2025 Jul;188:118213} {IF} {Rat}

    [IF={{ 6.2 }}] {Xiaomin Yang. et al. Crotonaldehyde paralyzes arteries by inducing impairment of ion channels, vascular histiocytic injury, overproduction of reactive oxygen species, mitochondrial damage, and autophagy. ECOTOX ENVIRON SAFE. 2024 Oct;285:117083} {IF} {Rat}

    [IF={{ 5.4 }}] {Xiaojia Xu. et al. Anji white tea relaxes precontracted arteries, represses voltage-gated Ca2+ channels and voltage-gated K+ channels in the arterial smooth muscle cells: Comparison with green tea main component (−)-epigallocatechin gallate. J ETHNOPHARMACOL. 2024 Feb;:117855} {IF} {Rat}

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    文献支持
    Kv1.2 Rabbit pAb(bs-16865R)-50ul/100ul/200ul
    ￥1180 - 2800