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H9N2 Hemagglutinin HA1 Rabbit

pAb(bs-16644R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-16644R
  • 2025年10月16日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-16644R
    英文名称H9N2 Hemagglutinin HA1 Rabbit pAb
    中文名称A型流感病毒（H9N2）血凝素HA1抗体
    英文别名ha; HA1; HA2; Hemagglutinin; HEMA_I66A1; Hemagglutinin HA1 chain; Hemagglutinin HA2 chain; Hemagglutinin precursor; Influenza A virus(strain A/Turkey/Wisconsin/1/1966 H9N2).
    产品应用ELISA=1:5000-10000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应 (Reacts with Avian Influenza A (H9N2) Hemagglutinin)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from Influenza A Hemagglutin HA1 Influenza A Hemagglutin HA1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量61 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Microbiology > Organism > Virus > RNA Virus > single stranded RNA negative strand virus > Influenza

    亚基Homotrimer of disulfide-linked HA1-HA2. Virion membrane; Single-pass type I membrane protein (Potential). Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
    亚细胞定位Cell Membrane
    翻译后修饰In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by Clara cells (By similarity).
    Palmitoylated (By similarity).
    相似性Belongs to the influenza viruses hemagglutinin family.
    功能Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent athway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.

     

    应用推荐稀释比例
    {ELISA}{1:5000-10000}

     

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    该产品被引用文献

    [IF={{ 15.8 }}] {Xiang Zhang. et al. Local and Noninvasive Glyco-Virus Checkpoint Nanoblockades Restrict Sialylation for Prolonged Broad-Spectrum Epidemic Virus Therapy. ACS NANO. 2024;XXXX(XXX):XXX-XXX} {WB} {Human}

    相关实验

    • 禽流感

      )、半乳糖、甘露糖、墨角藻糖和氨基葡糖，在病毒粒子中主要以糖蛋白或糖脂的形式存在。 　　病毒蛋白及潜在的糖基化位点是病毒基因组特异的，但病毒膜的糖蛋白或糖类链的脂质和碳水化合物链的成分，是由宿主细胞确定的。 抗原解释 　　流感病毒的抗原结构分为H和N两大类。H代表Hemagglutinin(血细胞凝集素)，有如病毒的钥匙，用来打开及入侵人类或牲畜的细胞；N代表神经氨酸酶(Neuramidinase)，是帮助病毒感染其他细菌的酵素。 病毒抵抗力 　　禽流感

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    H9N2 Hemagglutinin HA1 Rabbit pAb(bs-16644R)-50ul/100ul/200ul
    ￥1180 - 2800