MRGBP | C20orf20 Rabbit pAb(bs-15104R)-50ul/100ul/200ul产品图

MRGBP | C20orf20 Rabbit pAb(bs

-15104R)-50ul/100ul/200ul
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  • ¥1180 - 2800
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  • bs-15104R
  • 2026年10月14日
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    • 规格:

      50ul/100ul/200ul

    规格:50ul产品价格:¥1180.0
    规格:100ul产品价格:¥1980.0
    规格:200ul产品价格:¥2800.0
    产品编号bs-15104R
    英文名称C20orf20 Rabbit pAb
    中文名称20号染色体开放阅读框20抗体
    英文别名C20orf20; Chromosome 20 open reading frame 20; Eaf7; FLJ10914; MRG(MORF4 related gene) binding protein; MRG binding protein; MRG-binding protein; MRG/MORF4L binding protein; MRG15BP; MRGBP; MRGBP_HUMAN; OTTHUMP00000031512; URCC4.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Mouse, Rat)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human C20orf20
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量22 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚基Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX.
    亚细胞定位Nucleus.
    相似性Belongs to the EAF7 family.
    功能Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Proteins expressed in the endoplasmic reticulum (ER) are tightly regulated by a variety of quality control mechanisms. Terminally misfolded proteins in the ER are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM2 (ER degradation-enhancing alpha-mannosidase-like 2) is a 578 amino acid secreted protein that, in conjunction with other EDEM proteins (namely EDEM and EDEM3), is involved in the ERAD pathway of protein degradation. EDEM2, a member of the glycosyl hydrolase 47 family, contains a mannosidase homology domain, an N-terminal cleavable signal sequence and a C-terminal extension that is required for both ER retention and the proper function of EDEM2. Human EDEM2 shares 93% sequence identity with its mouse homolog, suggesting a conserved role between species. Two isoforms of EDEM2 exist due to alternative splicing events.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    产品细节图片1
    Sample: PC-3 (human)cell Lysate at 40 ug
    _x000D_ Primary: Anti- C20orf20 (bs-15104R)at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 22kD
    _x000D_ Observed band size: 22kD
    _x000D_ _x000D_

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    MRGBP | C20orf20 Rabbit pAb(bs-15104R)-50ul/100ul/200ul
    ¥1180 - 2800