UBE2J2 Rabbit pAb(bs-8381R)-50ul/100ul/200ul产品图

UBE2J2 Rabbit pAb(bs-8381R)-50

ul/100ul/200ul
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  • ¥1180 - 2800
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  • bs-8381R
  • 2026年10月14日
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      50ul/100ul/200ul

    规格:50ul产品价格:¥1180.0
    规格:100ul产品价格:¥1980.0
    规格:200ul产品价格:¥2800.0
    产品编号bs-8381R
    英文名称UBE2J2 Rabbit pAb
    中文名称泛素蛋白连接酶J2抗体
    英文别名NCUBE-2; NCUBE2; Non-canonical ubiquitin-conjugating enzyme 2; UB2J2_HUMAN; UBC6; UBC6 homolog; ube2j2; Ubiquitin-conjugating enzyme E2 J2.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human UBE2J2
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量29 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E2 Enzymes

    Epigenetics and Nuclear Signaling > Ubiquitin & Ubiquitin Like Modifiers > E2 Ubiquitin Conjugating Enzymes

    亚细胞定位Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity).
    相似性Belongs to the ubiquitin-conjugating enzyme family.
    功能Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity).
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Ubiquitination is an important molecular mechanism by which abnormal or short-lived proteins are targeted for degradation by the concerted efforts of at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2J2 (Ubiquitin-conjugating enzyme E2 J2), also known as NCUBE2 (Non-canonical ubiquitin-conjugating enzyme 2), is a 259 amino acid single pass type IV membrane protein that that belongs to the E2 ubiquitin-conjugating enzyme family and is involved in protein degradation. Localized to the membrane of the endoplasmic reticulum (ER), UBE2J2 catalyzes the attachment of ubiquitin to misfolded membrane proteins, thereby targeting them for proteasomal destruction. This ATP-dependent reaction yields AMP, a diphosphate and a ubiquitin-tagged protein and may be a method of quality control within the ER. Two isoforms of UBE2J2 exist due to alternative splicing events.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    产品细节图片1
    _x000D_ Sample:
    _x000D_ 293T(Human) Cell Lysate at 30 ug
    _x000D_ Primary: Anti-UBE2J2 (bs-8381R) at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 29 kD
    _x000D_ Observed band size: 29 kD
    _x000D_
    产品细节图片2
    Sample:
    _x000D_ 293T(Human) Cell Lysate at 40 ug
    _x000D_ Primary: Anti-UBE2J2 (bs-8381R) at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 29 kD
    _x000D_ Observed band size: 29 kD
    _x000D_

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    ¥1180 - 2800