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- 2025年10月16日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-6757R |
| 英文名称 | BCA2 Rabbit pAb |
| 中文名称 | 乳腺癌相关基因2抗体 |
| 英文别名 | BCA2; Breast cancer associated gene 2; CL469780; Rabring 7; RING finger protein 115; RNF115; Zinc finger protein 364; ZNF364; ZNF 364; RN115_HUMAN. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Pig, Cow, Horse, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ZNF364/BCA2/RNF115 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 34 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor biomarkers Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > RING Finger E3 Ligase Tags & Cell Markers > Cell Type Markers > Tumor Associated |
| 亚基 | Interacts with RAB7A. |
| 亚细胞定位 | Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes (By similarity). |
| 组织特异性 | Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. |
| 翻译后修饰 | RING-type zinc finger-dependent and E2-dependent autoubiquitination. |
| 相似性 | Contains 1 RING-type zinc finger. |
| 功能 | Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 5.033 }}] {Xiao-Ting Wu. et al. RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination. Cancer Metab. 2021 Dec;9(1):1-12} {WB,IHC} {Human}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
高效剥离液进行全自动运作。 6、 客户可通过电子邮件等方式获得结果照片及实验流程等全部实验数据、由我们专业的技术员进行灰度分析，并给出数据报告。 一、材料与方法： 1．试剂 Protein lysis buffer P001 BCA Protein Assay Kit cwbiotech 02912E Protein ladder Biomed PVDF
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
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