BRD8 Rabbit pAb(bs-6290R)-50ul/100ul/200ul产品图

BRD8 Rabbit pAb(bs-6290R)-50ul

/100ul/200ul
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  • ￥1180 - 2800
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  • bs-6290R
  • 2026年10月14日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-6290R
    英文名称BRD8 Rabbit pAb
    中文名称甲状腺激素受体共激活蛋白抗体
    英文别名BRD8; Bromodomain containing 8; p120; Skeletal muscle abundant protein 2; Skeletal Muscle Abundant Protein; SMAP; SMAP2; Thyroid hormone receptor coactivating protein 120kDa; Thyroid Hormone Receptor Coactivating Protein; BRD8_HUMAN.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Rat (Human, Mouse, Dog, Pig, Cow, Horse, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human BRD8
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量135 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell Death > Apoptosis > Metabolism

    Cancer > Cell Death > Apoptosis > Nucleus

    Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors > Coactivators and repressors

    Cell Biology > Apoptosis > Nucleus

    Epigenetics and Nuclear Signaling > Bromodomains

    Epigenetics and Nuclear Signaling > Cell cycle > Apoptosis > Nuclear

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HAT

    Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors

    Epigenetics and Nuclear Signaling > Transcription > Bromodomain containing

    Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes

    Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors

    Epigenetics and Nuclear Signaling > Transcription > Other factors

    Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription

    Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

    Metabolism > Pathways and Processes > Metabolism processes > Apoptosis

    Microbiology > Interspecies Interaction > Host Virus Interaction

    Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Co-activators/co-repressors

    亚基Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. BRD8 isoform 2 interacts with RXRA/NR2B1 and THRB/ERBA2
    亚细胞定位Nucleus.
    组织特异性Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
    相似性Contains 2 bromo domains.
    功能BRD8 may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. It interacts with MYC and adenovirus E1A protein.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}
    {ELISA}{1:5000-10000}

     

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    BRD8 Rabbit pAb(bs-6290R)-50ul/100ul/200ul
    ￥1180 - 2800