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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-15457R |
| 英文名称 | HEV Capsid protein Rabbit pAb |
| 中文名称 | 戊型肝炎病毒抗体 |
| 英文别名 | HEV; CAPSD_HEVMG; Capsid protein; Protein ORF2; pORF2; Hepatitis E Virus Capsid protein. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Hepatitis E Virus) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from Hepatitis E Virus Capsid protein |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 69 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > Hepatitis A/C/E/G |
| 亚基 | Homodimers. Homooligomer. Self-assembles to form the capsid. The capsid is dominated by dimers that define the 30 morphological units. The unglycosylated form interacts with the phosphorylated ORF3 protein . |
| 亚细胞定位 | Virion (Probable). Host cytoplasm. Host cell surface. Note=Initially cotranslationally translocated into the ER from where it is retrotranslocated to the cytoplasm. A fraction is also observed on the cell surface. |
| 翻译后修饰 | Glycosylated when overexpressed in mammalian cells. In vivo, the glycosylated form is probably much less stable than the non-glycosylated form, which is present in the cytosol and represents the major product accumulated in the cell. May be present initially as a glycosylated protein in the ER, and may become unglycosylated and retrotranslocated to the cytoplasm by the endoplasmic reticulum-associated degradation (ERAD) system. The non-glycosylated form may therefore be the authentic intermediate in HEV capsid assembly (By similarity). |
| 相似性 | Belongs to the hepevirus capsid protein family. |
| 功能 | Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Hepatitis E virus is the causative agent of Hepatitis E. Its taxonomic name is Orthohepevirus A. The viral genome a single-strand of positive-sense RNA that is approximately 7200 bases in length. It encodes 3 proteins (O1, O2, O3), two of which are polyproteins, that is, they are cleaved into fragments which carry out the actual functions of the virus. The O1 protein consists of 7 such fragments, namely Met (Methyltransferase), Y (Y-domain), Plp (Papain like protease), V (proline-rich variable region), X (X-domain, macro-domain), Hel (Helicase), and Rdrp (RNA dependent RNA polymerase). The Pvx domain is a fusion protein consisting of the Plp, V and X domains. The O3 protein is encoded by a single open reading frame (ORF3). The O2 protein encodes the capsid, which is composed of 3 domains, namely the shell domain (S) and two protruding domains (P1, P2). Numbers in the figure indicate positions in the RNA sequence. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 5.776 }}] {Wang L et al. Presence and persistence of hepatitis E virus RNA and proteins in Human bone marrow. Emerg Microbes Infect. 2020 Dec;9(1):994-997.} {IHC} {Human}
[IF={{ 3.561 }}] {Li S et al. Characterization of hepatitis E virus natural infection in farmed rabbits J Viral Hepat. 2020 Aug 27.} {IF} {rabbit}
[IF={{ }}] {Li S et al . Infectivity and pathogenicity of different hepatitis E virus genotypes/subtypes in rabbit model. Emerg Microbes Infect. 2020 Nov 29;1-28.} {Other} {}
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
scale. Methods Mol. Biol. 375:57‐78. Li, Q.Z., Zhou, J., Wandstrat, A.E., Carr‐Johnson, F., Branch, V., Karp, D.R., Mohan, C., Wakeland, E.K., and Olsen, N.J. 2007. Protein
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
capsid. It was found that internal regions of the phage genome, which were not essential to phage replication, could be removed and replaced with DNA of interest. This hybrid DNA could be efficiently packaged, and form an infective phage
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