ADGRG6 | GPR126 Rabbit pAb(bs-12027R)-50ul/100ul/200ul产品图

ADGRG6 | GPR126 Rabbit pAb(bs-

12027R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-12027R
  • 2026年10月14日
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    北京博奥森生物技术有限公司
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    • 规格：

      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-12027R
    英文名称GPR126 Rabbit pAb
    中文名称G蛋白偶联受体126抗体
    英文别名APG1; Developmentally regulated G-protein-coupled receptor; dj287g14.2; DREG; G-protein coupled receptor 126; GP126_HUMAN; GPR126; HBV PreS1-transactivated protein 2; OTTHUMP00000017320; OTTHUMP00000237093; OTTHUMP00000237094; OTTHUMP00000237115; Probable G-protein coupled receptor 126 [Precursor]; Probable G-protein coupled receptor 126; PS1TP2; Vascular inducible G protein-coupled receptor; VIGR; GPCR GPR126.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应 (Human, Mouse, Rat, Cow, Rabbit, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human G-protein coupled receptor 126
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量139 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR

    亚细胞定位Cell membrane. Detected on the cell surface of activated but not resting umbilical vein.
    组织特异性Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
    翻译后修饰Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site.
    相似性Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    _x000D_ Contains 1 CUB domain.
    _x000D_ Contains 1 GPS domain.
    _x000D_ Contains 1 pentaxin domain.
    功能Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR126 (G protein-coupled receptor 126), also known as APG1, DREG, VIGR or PS1TP2, is a 1,221 amino acid multi-pass membrane protein that contains one pentaxin domain, one GPS domain and one CUB domain. Existing as three alternatively spliced isoforms, GPR126 functions as an orphan G protein-coupled receptor that, when subject to genetic variation, may influence stature and adult height.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {ICC/IF}{1:100-500}
    {IF}{1:100-500}
    {ELISA}{1:5000-10000}

     

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    ￥1180 - 2800