Sample:
HepG2(Human) Cell Lysate at 30 ug
NIH/3T3(Mouse) Cell Lysate at 30 ug
K562(Human) Lysate at 30 ug
Heart (Mouse) Lysate at 40 ug
Primary: Anti-FNDC5 (bs-8486R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 12/20 kD
Observed band size: 20 kD
- ￥1180 - 2800
- Bioss
- bs-8486R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8486R |
| 英文名称 | FNDC5 Rabbit pAb |
| 中文名称 | Ⅲ型纤维连接蛋白域蛋白2/5抗体 |
| 英文别名 | Fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat containing protein 2; Fibronectin type III repeat-containing protein 2; FNDC 5; FNDC5_HUMAN; FRCP2; Irisin. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Chicken, Dog, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human FNDC5 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 12/20 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies Metabolism > Types of disease > Obesity |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway. Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. |
| 翻译后修饰 | The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. |
| 相似性 | Contains 1 fibronectin type-III domain. |
| 功能 | Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 7.31 }}] {Chen Taiqiu. et al. Irisin Ameliorates Intervertebral Disc Degeneration by Activating LATS/YAP/CTGF Signaling. OXID MED CELL LONGEV. 2022;2022:9684062} {WB} {Human}
[IF={{ 6.291 }}] {Shou-En Wu. et al. Benzo[a]pyrene exposure in muscle triggers sarcopenia through aryl hydrocarbon receptor-mediated reactive oxygen species production. ECOTOX ENVIRON SAFE. 2022 Jul;239:113599} {WB} {Mouse}
[IF={{ 6.208 }}] {Chuanxi Tang. et al. Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson’s Disease. INT J MOL SCI. 2023 Jan;24(9):7830} {WB,CoIP} {Mouse,Mouse}
[IF={{ 6.081 }}] {Daniel Norman. et al. Irisin—A Pancreatic Islet Hormone. Biomedicines. 2022 Feb;10(2):258} {IHC} {Rat,Human}
[IF={{ 5.895 }}] {Guangning Kou. et al. Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway. J AGR FOOD CHEM. 2022;XXXX(XXX):XXX-XXX} {IF,IHC,WB} {Mouse}
相关实验
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FNDC5 Rabbit pAb(bs-8486R)-50ul/100ul/200ul
￥1180 - 2800
