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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-14723R |
| 英文名称 | C1QTNF12 Rabbit pAb |
| 中文名称 | 脂肪源性胰岛素增敏因子抗体 |
| 英文别名 | Adipolin; Adipose derived insulin sensitizing factor; C1q domain containing 2; C1q/TNF related protein 12; C1QDC2; CTRP12; F132A_HUMAN; Fam132a; Protein FAM132A. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human C1QTNF12 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 30 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies |
| 亚基 | Homomultimer; disulfide-linked. May interact with ERFE (By similarity). |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Predominantly expressed by adipose tissues. |
| 翻译后修饰 | Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN. Insulin enhances endogenous C1QTNF12 cleavage. |
| 相似性 | Belongs to the FAM132 family. |
| 功能 | Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The FAM132A gene product has been provisionally designated FAM132A pending further characterization. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
sapiens chromosome 5 clone ... 40 2.1 gi|19310326|gb|AC105250.3| Homo sapiens BAC clone RP11-39C1... 40 2.1 gi|37537322|dbj|BS000055.1| Pan troglodytes chromosome 22 c... 40 2.1 gi|37537321|dbj|BS000054.1| Pan troglodytes chromosome 22 c... 40 2.1 gi
)测试中，其变化规律与补体的变化趋势有显著的相关性(C3、C4与IgGr=0.6683；0.6439；与IgM r=0.5805；0.6296；与IgA r=0.7569；0.9302)。表明补体水平的变化与抗体的变化直接有关。 （3）运动时内环境理化因素的改变：补体系统存在经典激活途径与旁路激活途径。补体一旦被激活后，被激活的裂解产物会产生酶样作用，依次激活下一补体，即逐步由识别阶段(C1q，C1r及C1s)过渡到效应阶段(C2、C3、C4、C5)与膜攻击阶段(C6-C9)。而由于运动中大量消耗
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