Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Heart tissue lysates
Primary: Anti-FADS2 (bs-11516R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kDa
Observed band size: 47 kDa
- ￥1180 - 2800
- Bioss
- bs-11516R
- 2025年10月24日
- 产品信息以Bioss网站为准
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-11516R |
| 英文名称 | FADS2 Rabbit pAb |
| 中文名称 | 脂肪酸脱氢酶2抗体 |
| 英文别名 | D6D; delta(6) desaturase; delta(6) fatty acid desaturase; DES 6; DES6; FADS 2; FADSD 6; FADSD6; Fatty acid desaturase 2; linoleoyl-CoA desaturase(delta-6-desaturase) like 2; LLCDL 2; LLCDL2; SLL0262; TU 13; TU13; FADS2_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Mouse (Human, Rat, Chicken, Pig, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human FADS2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 52 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Metabolism Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Fatty acids Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation Neuroscience > Neurology process > Metabolism Signal Transduction > Metabolism > Lipid metabolism |
| 亚细胞定位 | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| 组织特异性 | Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic index. |
| 相似性 | Belongs to the fatty acid desaturase family. Contains 1 cytochrome b5 heme-binding domain. |
| 功能 | FADS2 (Fatty acid desaturase 2) catalyses the biosynthesis of highly unsaturated fatty acids from precursor essential polyunsaturated fatty acids (linoleic and alpha-linoleic acid). FADS family members comprise an N-terminal cytochrome b5-like domain and a C-terminal membrane-spanning desaturase. FADS2 is repressed by dietary highly unsaturated fatty acids. Altered expression of FADS2 may be associated with obesity-associated insulin resistance. Genetic studies have linked FADS2 to IQ and attention-deficit/hyperactivity disorder (ADHD). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the fatty acid desaturase (FADS) family, including FADS1, FADS2 and FADS3, regulate the desaturation of fatty acids by introducing double bonds between defined carbons of fatty acyl chains, thereby playing an essential role in the lipid metabolic pathway. Members of this family share N-terminal cytochrome b5-like domains, C-terminal multiple membrane-spanning desaturase regions and 3 histidine box motifs. FADS2 (fatty acid desaturase 2), also known as D6D, DES6, LLCDL2 or TU13, is a 444 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one cytochrome b5 heme-binding domain. Expressed in adult and fetal heart and in adult liver, brain, lung and retina, FADS2 functions as a component of a lipid metabolic pathway and catalyzes the first step in the pathway, namely the formation of unsaturated fatty acids from polyunsaturated fatty acids. Defects in the gene encoding FADS2 are the cause of cause of fatty acid delta-6-desaturase deficiency, an affliction that is characterized by skin abnormalities, corneal ulceration and growth failure. Multiple isoforms of FADS2 exist due to alternative splicing events. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 8.5 }}] {Zihong Li. et al. Fatty acid desaturase 2 (FADS2) affects the pluripotency of hESCs by regulating energy metabolism. INT J BIOL MACROMOL. 2025 Mar;295:139449} {IF,WB} {Human}
[IF={{ 3.701 }}] {Xiaoxia Liu. et al. EGCG regulates fatty acid metabolism of high-fat diet-fed mice in association with enrichment of gut Akkermansia muciniphila. J Funct Foods. 2020 Dec;75:104261} {IHC} {Mouse}
[IF={{ 2.752 }}] {Xuchun Liu. et al. The Effect of FATP1 on Adipocyte Differentiation in Qinchuan Beef Cattle. Animals-Basel. 2021 Oct;11(10):2789} {WB} {Bovine}
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FADS2 Rabbit pAb(bs-11516R)-50ul/100ul/200ul
￥1180 - 2800
