Sample:
Lane1:Heart (Rat)Lysate at 40 ug
Lane2:Heart (Mouse) Lysate at 40 ug
Primary: Anti-Endothelin B Receptor(bs-4198R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 47kD
Observed band size: 50kD
- ￥1180 - 2800
- Bioss
- bs-4198R
- 2025年10月16日
- 产品信息以Bioss网站为准
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-4198R |
| 英文名称 | Endothelin B Receptor Rabbit pAb |
| 中文名称 | 内皮素B受体抗体 |
| 英文别名 | ABCDS; Ednra; Ednrb; EDNRB_HUMAN; Endothelin B receptor; Endothelin B receptor precursor; Endothelin receptor Non selective type; Endothelin receptor non-selective type; Endothelin receptor type B; ET B; ET-B; ET-BR; ETB; ETRB; Hirschsprung disease 2; HSCR; HSCR2; EDNRB; HSCR; WS4A. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Chicken, Dog, Pig, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Endothelin B Receptor |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 47 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. |
| 翻译后修饰 | Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. |
| 功能 | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Endothelin receptor type B (ETRB) is a G protein-coupled receptor that activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. A splice variant (SVR), differing in the intracellular C terminal domain, has been described for this receptor. Both WT and the variant bind ET1. However, they exhibit different responses upon binding - suggesting that these two variants are functionally distinct. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
Lane 1: Embryo (Mouse) Tissue Lysate at 40 ug
Lane 2: Lung (Mouse) TissueLysate at 40 ug
Lane 3: Cerebrum (Mouse) Tissue Lysate at 40 ug
Lane 4: Cerebrum (Rat) Tissue Lysate at 40 ug
Lane 5: A431 (Human) Cell Lysate at 30 ug
Lane 6: BV-2 (Mouse) Cell Lysate at 30 ug
Lane 7: SH-SY5Y (Human) Cell Lysate at 30 ug
Primary: Anti-Endothelin B Receptor (bs-4198R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 47 kD
Observed band size: 50 kD
Lane 1: Embryo (Mouse) Tissue Lysate at 40 ug
Lane 2: Lung (Mouse) TissueLysate at 40 ug
Lane 3: Cerebrum (Mouse) Tissue Lysate at 40 ug
Lane 4: Cerebrum (Rat) Tissue Lysate at 40 ug
Lane 5: A431 (Human) Cell Lysate at 30 ug
Lane 6: BV-2 (Mouse) Cell Lysate at 30 ug
Lane 7: SH-SY5Y (Human) Cell Lysate at 30 ug
Primary: Anti-Endothelin B Receptor (bs-4198R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 47 kD
Observed band size: 50 kD
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文献和实验该产品被引用文献
[IF={{ 4.757 }}] {Nataliia Hula. et al. The Long-Term Effects of Prenatal Hypoxia on Coronary Artery Function of the Male and Female Offspring. BIOMEDICINES. 2022 Dec;10(12):3019} {IF} {Rat}
[IF={{ 2.107 }}] {Ji L et al. A high affinity nanobody against endothelin receptor type B: a new approach to the treatment of melanoma. Mol Biol Rep. 2020 Mar;47(3):2137-2147.} {WB} {Human}
[IF={{ 10.787 }}] {Ravi Kumar. et al. Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cells. REDOX BIOL. 2022 Sep;55:102394} {WB} {Pig}
[IF={{ 0.939 }}] {Prayitnaningsih et al. Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats. (2016) Int.J.Ophthalmol. 9:1568-1577} {IF} {Rat}
相关实验
Overview of Receptor Allosterism
Figure 1.21.2 Effect of: (A ) negative allosteric modulator, (B ) positive allosteric modulator, or (C ) a competitive antagonist on orthosteric ligand‐receptor occupancy (ρA ). For all the simulations, p K
，Mus musculus是小鼠的学名，由于我的目标是小数的ednrb基因，故选择Mus musculus。 3: 对Official Symbol Ednrb and Name: endothelin receptor type B [Mus musculus] Other Aliases: AU022549, ET-B, ET>B Other Designations: piebald Chromosome: 14; Location: 14 51.0 cM
(IKK-α β γ )-associated protein; Iκ B, inhibitor of NFκ B; IRAK, IL-1R-associated kinase; LTA, lipoteichoic acid; NIK, NFκ B-inducing kinase; PGN, peptidoglycan; RIP, receptor-interacting protein; TNF, tumour necrosis
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Endothelin B Receptor Rabbit pAb(bs-4198R)-50ul/100ul/200ul
￥1180 - 2800
