Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-DR6 (bs-7678R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52/68 kD
Observed band size: 52 kD
- ￥1180 - 2800
- Bioss
- bs-7678R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-7678R |
| 英文名称 | DR6 Rabbit pAb |
| 中文名称 | 肿瘤细胞调亡素/肿瘤坏死因子受体死亡受体6抗体 |
| 英文别名 | TNFRSF 21; BM 018; BM018; CD358; Death receptor 6; DR 6; MGC31965; TNFR related death receptor 6; TNFRSF21; TNFRSF21 protein; TNR21_HUMAN; Tumor necrosis factor receptor superfamily member 21; Tumor necrosis factor receptor superfamily member 21 precursor. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Mouse, Rat (Human, Chicken, Dog, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DR6/CD358 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 52/68 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Associates with TRADD. Interacts with N-APP (By similarity). |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein (Probable). |
| 组织特异性 | Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. |
| 相似性 | Contains 1 death domain. Contains 4 TNFR-Cys repeats. |
| 功能 | May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).Tissue specificity: Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample: Heart (Mouse) Lysate at 40 ug
Primary: Anti-DR6 (bs-7678R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52/68 kD
Observed band size: 52 kD
Primary: Anti-DR6 (bs-7678R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52/68 kD
Observed band size: 52 kD
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文献和实验该产品被引用文献
[IF={{ 9 }}] {Huang Xiaomin. et al. Endothelial DR6 in blood-brain barrier malfunction in Alzheimer’s disease. CELL DEATH DIS. 2024 Apr;15(4):1-11} {IF,WB} {Mouse}
[IF={{ 6.9 }}] {Major Enikő. et al. LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10. ACTA PHARMACOL SIN. 2024 Aug;:1-9} {FCM} {Human}
[IF={{ 40.137 }}] {Strilic, Boris, et al. "Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis." Nature (2016).} {IF} {Mouse&Human}
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DR6 Rabbit pAb(bs-7678R)-50ul/100ul/200ul
￥1180 - 2800
