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- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-0093R |
| 英文名称 | TNF beta Rabbit pAb |
| 中文名称 | 肿瘤坏死因子β抗体 |
| 英文别名 | TNF-beta; LTalpha; Coley’s toxin; DIF; Differentiation inducing factor; Hemorrhagic factor; LT alpha; LT; LTA; Lymphotoxin alpha(TNF superfamily, member 1); Lymphotoxin alpha; Natural killer cytotoxic factor; Necrosin; NKCF; OTTHUMP00000037612; OTTHUMP00000037613; TNF B; TNF superfamily member 1; TNFbeta; TNFSF 1; TNFSF1; Tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNFB_HUMAN; |
| 中文别名 | TNF β; TNF-β. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Dog, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TNF beta |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 18 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Growth factors > TNF Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors Immunology > Innate Immunity > Cytokines > Necrosis Factors Immunology > Innate Immunity > Cytokines > TNF Superfamily Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Cytokines and cytokine receptors ELISA kits Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > TNF ELISA kits Signal Transduction > Growth Factors/Hormones > TNF |
| 亚基 | Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. |
| 亚细胞定位 | Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. |
| 相似性 | Belongs to the tumor necrosis factor family. |
| 功能 | Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Gene Symbol: TNF-Beta; tumor necrosis factor-Beta; Tumor necrosis factor ligand superfamily member 1; TNFSF1; LTA; Lymphotoxin-alpha; TNF-beta; LT-alpha. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 2.738 }}] {Liang Wang et al. Clinical Significance of M1/M2 Macrophages and Related Cytokines in Patients with Spinal Tuberculosis. Dis Markers. 2020 May 20;2020:2509454.} {IHC} {Human}
[IF={{ 1.826 }}] {Fei W et al. The effects of aqueous extract of Maca on energy metabolism and immunoregulation. Eur J Med Res. 2020 Jun 29;25(1):24.} {WB} {Mouse}
(IKK-α β γ )-associated protein; Iκ B, inhibitor of NFκ B; IRAK, IL-1R-associated kinase; LTA, lipoteichoic acid; NIK, NFκ B-inducing kinase; PGN, peptidoglycan; RIP, receptor-interacting protein; TNF, tumour necrosis
Protocol for intracytoplasmic staining of cytokines for FACS analysis
; Pharmingen 18195A) for FL2 anti-IL10 (JES5.16E3-PE; Pharmingen 18435A) for FL1 anti-TGF-beta (rabbit anti pan TGF-beta; R&D Systems AB-100-NA home made FITC conjugate) for FL2 8) Wash extensively in saponin buffer followed by PBS + 0.1% azide
Protocol for intracytoplasmic staining of cytokines for FACS analysis
; Pharmingen 18195A) for FL2 anti-IL10 (JES5.16E3-PE; Pharmingen 18435A) for FL1 anti-TGF-beta (rabbit anti pan TGF-beta; R&D Systems AB-100-NA home made FITC conjugate) for FL2 8) Wash extensively in saponin buffer followed by PBS + 0.1% azide
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