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- 2025年10月24日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2901R |
| 英文名称 | RECK Rabbit pAb |
| 中文名称 | 金属蛋白酶抑制因子RECK抗体 |
| 英文别名 | hRECK; Membrane anchored glycoprotein(metastasis and invasion); RECK protein; Reversion inducing cysteine rich protein with Kazal motifs; ST15; Suppression of tumorigenicity 15(reversion inducing cysteine rich protein with kazal motifs); Suppressor of tumorigenicity 15; RECK_HUMAN. |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Dog, Pig, Cow, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human RECK |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 107 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors Cell Biology > Proteolysis / Ubiquitin > Protease inhibitors > Serine protease inhibitors > RECK |
| 亚基 | Interacts with MMP-9. |
| 亚细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor. |
| 组织特异性 | Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Contains 3 Kazal-like domains. |
| 功能 | Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | RECK is a cysteine rich, extracellular protein with protease inhibitor like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase 9, a key enzyme involved in tumor invasion and metastasis. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 4.22 }}] {Siddesha, Jalahalli M., et al. ʺAcetylsalicylic Acid Inhibits IL‐18‐Induced Cardiac Fibroblast Migration through the Induction of RECK.ʺ Journal of cellular physiology (2013).} {Other} {="Mouse"}
[IF={{ 3.309 }}] {Liu L et al. Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury.Exp Cell Res. 2018 Sep 15;370(2):198-207.} {WB} {Rat&Human}
[IF={{ 2.511 }}] {Zhou L et al. The role of miR-21/RECK in the inhibition of osteosarcoma by curcumin. Mol Cell Probes. 2020 Feb 17:101534.} {WB} {Human}
[IF={{ 1.03 }}] {Liu, Jianfeng, et al. "RECK is involved in intimal hyperplasia in carotid arteries: A new insight in the prevention of restenosis after vascular angioplasty."Annals of Vascular Surgery (2015).} {WB} {="Human"}
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