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Adiponectin Receptor 1 Rabbit

pAb(bs-0610R)-50ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-0610R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0610R
    英文名称Adiponectin Receptor 1 Rabbit pAb
    中文名称脂联素受体1抗体
    英文别名ACDCR1; ADIPO R1; Adiponectin receptor protein 1; ADIPOR 1; ADIPOR1; CGI-45; CGI-45 protein; FLJ25385; PAQR1; Progestin and adipoQ receptor family member I; TESBP1A; ADR1_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Chicken, Dog, Rabbit)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Adiponectin Receptor 1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量42 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Lipids / Lipoproteins > Adipose Related > Acrp

    Signal Transduction > Growth Factors/Hormones > Hormones

    亚基May form homo and heteromultimers.
    亚细胞定位Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles.
    组织特异性Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
    相似性Belongs to the ADIPOR family.
    功能Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR- . Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Tissue/cell: human rectal tissue; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min;
    Incubation: Anti-Adiponectin Receptor 1 Polyclonal Antibody, Unconjugated(bs-0610R) 1:300, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    产品细节图片2
    Tissue/cell: rat pancreas tissue; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min;
    Incubation: Anti-Adiponectin Receptor 1 Polyclonal Antibody, Unconjugated(bs-0610R) 1:300, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    产品细节图片3
    Sample: Muscle(Mouse) Lysate at 40 ug
    Primary: Anti- Adiponectin Receptor 1 (bs-0610R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 42 kD
    Observed band size: 42 kD
    产品细节图片4
    Sample:
    Lane 1: Mouse Muscle tissue lysates
    Lane 2: Mouse Breast tissue lysates
    Lane 3: Mouse Heart tissue lysates
    Lane 4: Rat Muscle tissue lysates
    Lane 5: Rat Heart tissue lysates
    Primary: Anti-Adiponectin Receptor 1 (bs-0610R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 42 kDa
    Observed band size: 42 kDa

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    图标文献和实验
    该产品被引用文献

    [IF={{ 6.9 }}] {Ze Peng. et al. 6-Gingerol improves lipid metabolism disorders in skeletal muscle by regulating AdipoR1/AMPK signaling pathway. BIOMED PHARMACOTHER. 2024 Nov;180:117462} {IF,WB} {Mouse}

    [IF={{ 6.43 }}] {Morad, Vivian, Annelie Abrahamsson, and Charlotta Dabrosin. "Estradiol affects extracellular leptin: adiponectin ratio in human breast tissue in vivo." The Journal of Clinical Endocrinology & Metabolism (2014).} {IHC} {="Human"}

    [IF={{ 6.304 }}] {Jia Gao. et al. Nicotine aggravates vascular adiponectin resistance via ubiquitin-mediated adiponectin receptor degradation in diabetic Apolipoprotein E knockout mouse. Cell Death Dis. 2021 May;12(6):1-12} {WB,IF} {Human}

    [IF={{ 5.74 }}] {Liu, Gai-Zhen, et al. "High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation." Free Radical Biology and Medicine (2015).} {WB} {="Human"}

    [IF={{ 5.14 }}] {Wu, Ming-Hsiu, et al. "Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis."Molecular Neurobiology (2015): 1-12.} {WB} {="Rat"}

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      , Algermissen, B. et al. 3. Purification of rabbit liver aldehyde oxidase by affinity chromatography on benzamidine Sepharose 6B. J. Chromatogr. (1989), 475 363-72, Stell, J. G. P. et al. 4. The Crystal Structure of a T Cell Receptor in Complex

    • 细胞因子试剂盒免费实验代测

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    文献支持
    Adiponectin Receptor 1 Rabbit pAb(bs-0610R)-50ul/100ul/200ul
    ￥1180 - 2800