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- bs-20183R
- 2025年10月16日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-20183R |
| 英文名称 | CES2 Rabbit pAb |
| 中文名称 | 羧酸酯酶2抗体 |
| 英文别名 | Carboxylesterase 2(intestine, liver); Carboxylesterase 2; CE-2; CES2; CES2A1; Cocaine esterase; EC 3.1.1.1; EST2_HUMAN; hCE-2; ICE; Iintestinal carboxylesterase liver carboxylesterase 2; Intestinal carboxylesterase; liver carboxylesterase-2; Methylumbelliferyl acetate deacetylase 2; PCE 2; PCE-2. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CES2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 59 kDa |
| 浓度 | 1mg/ml |
| 储存液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 研究领域 | Metabolism > Pathways and Processes > Metabolic signaling pathways > Drug metabolism Signal Transduction > Metabolism > Drug metabolism Signal Transduction > Metabolism > Lipid metabolism |
| 亚细胞定位 | Endoplasmic reticulum lumen. |
| 组织特异性 | Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum. |
| 翻译后修饰 | Glycosylated. |
| 相似性 | Belongs to the type-B carboxylesterase/lipase family. |
| 功能 | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of Cocaine, 4-methyumbelliferyl acetate, heroin and 6-monoacetylMorphine. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as Cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010] |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验该产品被引用文献
[IF={{ 3.329 }}] {Zhang Y et al. Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway. Exp Cell Res. 2020 Jan 22:111856.} {WB} {Human}
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CES2 Rabbit pAb(bs-20183R)-50ul/100ul/200ul
￥1180 - 2800
