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SOCS7 Rabbit pAb(bs-20151R)-50

ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-20151R
  • 2025年10月16日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-20151R
    英文名称SOCS7 Rabbit pAb
    中文名称信号转导和转录激活因子7抗体
    英文别名NAP 4; NAP 4 Fragment; NAP4; Nck Ash and phospholipase C binding protein; Nck Ash and phospholipase C gamma binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS 7; SOCS4; SOCS6; Suppressor of cytokine signaling 7; SOCS7_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Rabbit)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human SOCS7
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量63 kDa
    浓度1mg/ml
    储存液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
    研究领域

    Signal Transduction > Adapters > Cytoplasmic

    亚基Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6.
    亚细胞定位Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
    组织特异性Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
    相似性Contains 1 SH2 domain.
    Contains 1 SOCS box domain.
    功能Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes. SOCS6 and SOCS7 are expressed ubiquitously in murine tissues and SOCS6 knockout mice are growth retarded.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:
    Lane 1: Cerebrum (Mouse) Lysate at 40 ug
    Lane 2: Cerebellum (Mouse) Lysate at 40 ug
    Lane 3: Testis (Mouse) Lysate at 40 ug
    Lane 4: Stomach (Mouse) Lysate at 40 ug
    Lane 5: Placenta (Mouse) Lysate at 40 ug
    Lane 6: Cerebrum (Rat) Lysate at 40 ug
    Lane 7: Cerebellum (Rat) Lysate at 40 ug
    Lane 8: Testis (Rat) Lysate at 40 ug
    Lane 9: HepG2 (Human) Cell Lysate at 30 ug
    Lane 10: Hela (Human) Cell Lysate at 30 ug
    Lane 11: MCF-7 (Human) Cell Lysate at 30 ug
    Lane 12: HL60 (Human) Cell Lysate at 30 ug
    Lane 13: Molt-4 (Human) Cell Lysate at 30 ug
    Primary:
    Anti-SOCS7 (bs-20151R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 63 kD
    Observed band size: 60 kD
    产品细节图片2
    Tissue/cell: Mouse embryo tissue; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    Incubation: Anti-SOCS7 Polyclonal Antibody, Unconjugated(bs-20151R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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    图标文献和实验
    该产品被引用文献

    [IF={{ 11.161 }}] {Du, Yanhua. et al. SOCS7/HuR/FOXM1 signaling axis inhibited high-grade serous ovarian carcinoma progression. J EXP CLIN CANC RES. 2022 Dec;41(1):1-16} {IHC} {Human}

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    SOCS7 Rabbit pAb(bs-20151R)-50ul/100ul/200ul
    ￥1180 - 2800