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CDCA3 Rabbit pAb(bs-7894R)-50u

l/100ul/200ul
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  • ¥1180 - 2800
  • Bioss已认证
  • bs-7894R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格:50ul产品价格:¥1180.0
    规格:100ul产品价格:¥1980.0
    规格:200ul产品价格:¥2800.0
    产品编号bs-7894R
    英文名称CDCA3 Rabbit pAb
    中文名称细胞分裂周期相关蛋白3抗体
    英文别名CDCA 3; Cell division cycle associated 3; Cell division cycle associated protein 3; Gene rich cluster C8; Gene rich cluster protein C8; GRCC 8; GRCC8; MGC2577; TOME 1; TOME1; Trigger of mitotic entry 1; C8 antibody; Trigger of mitotic entry protein 1; CDCA3_HUMAN .
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应 (Human, Mouse, Rat)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human CDCA3
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量29 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Cell Cycle > Kinases/Phosphatases > Cdk Regulators

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > SCF Complex E3 Ligase

    Epigenetics and Nuclear Signaling > Cell cycle > Kinases/Phosphatases > Cdk Regulators

    Epigenetics and Nuclear Signaling > Cell cycle > Ubiquitin ligases

    亚基Protein modification; protein ubiquitination. [SUBUNIT] Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).
    亚细胞定位Cytoplasm, cytosol (By similarity).
    翻译后修饰Ubiquitinated and degraded by the APC/C-Cdh1 complex (By similarity).
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    功能F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料CDCA3 (Cell division cycle associated 3) is an F-box-like protein which is required for entry into mitosis. It is associated with SKP1 as part of a SCF (SKP1-cullin-F-box) protein ligase complex, and is required for the ubiquitination and degradation of the CDK1 inhibitory tyrosine kinase WEE1 at G2/M phase.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}
    {ELISA}{1:5000-10000}

     

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    图标文献和实验
    该产品被引用文献

    [IF={{ 5.7 }}] {Zhou Mingxuan. et al. Identification of immune-related genes and small-molecule drugs in hypertension-induced left ventricular hypertrophy based on machine learning algorithms and molecular docking. FRONT IMMUNOL. 2024 Jun;15:} {IF,WB} {Mouse}

    [IF={{ 4.8 }}] {Daolin Ji. et al. The functional roles of deoxyelephantopin potential target circTNPO3 in regulating pancreatic cancer malignant phenotype and gemcitabine chemoresistance via miR-188-5p/CDCA3/TRAF2-mediated remodeling of NF-κB signaling pathway. FRONT PHARMACOL. 2025 Jul;16:1613560} {WB} {Human}

    [IF={{ 3.58 }}] {Wang, Qi, et al. "Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: In vivo and in vitro studies." Food and Chemical Toxicology (2017).} {WB} {="Rat"}

    [IF={{ 2.9 }}] {Wei Ding. et al. Roles of the CDCA gene family in breast carcinoma. SCI PROGRESS-UK. ;():} {WB,IHC} {Human}

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    文献支持
    CDCA3 Rabbit pAb(bs-7894R)-50ul/100ul/200ul
    ¥1180 - 2800