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- 2025年10月16日
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50ul/100ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 产品编号 | bs-7106R |
| 英文名称 | NUPR1 Rabbit pAb |
| 中文名称 | 核蛋白p8抗体 |
| 英文别名 | Candidate of metastasis 1; COM1; Nuclear protein 1; NUPR1; NUPR1_HUMAN; p8 protein; Protein p8. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human NUPR1/p8 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 9 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 |
Cancer > Cell Death > Apoptosis > Nucleus Cell Biology > Apoptosis > Nucleus Cell Biology > Cell Cycle > Markers |
| 亚基 | Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase complex; the interaction with MORF4L1 may be mediated by MSL1. |
| 亚细胞定位 |
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. |
| 组织特异性 | Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes. |
| 翻译后修饰 | Phosphorylated in vitro by PKA and CK. Phosphorylation promotes DNA-binding activity. |
| 相似性 | Belongs to the NUPR family. |
| 功能 | Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. May contribute to the metastatic phenotype.Tissue specificity: Highly expressed in pancreas. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Lane 1: Human L-O2 cell lysates
Lane 2: Human U87MG cell lysates
Primary: Anti-NUPR1 (bs-7106R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 9 kDa
Observed band size: 11 kDa
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文献和实验[IF={{ 7.126 }}] {Narzt et al. A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids. (2018) Redox.Biol. 20:467-482} {IF} {Human}
[IF={{ 6.1 }}] {Zhou Jie. et al. Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension. CELL BIOL TOXICOL. 2024 Dec;40(1):1-20} {IHC,IF} {Mouse}
[IF={{ 6.1 }}] {Liao Taiyang. et al. Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway. J TRANSL MED. 2024 Dec;22(1):1-14} {IF,WB} {Mouse}
[IF={{ 5.402 }}] {Li Tan. et al. Age-Related Decline in Expression of Molecular Chaperones Induces Endoplasmic Reticulum Stress and Chondrocyte Apoptosis in Articular Cartilage. Aging Dis. 2020 Oct; 11(5): 1091–1102} {IHC} {Monkey}
[IF={{ 5.391 }}] {Shiraki M et al. Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiationof osteoclasts and enhancing differentiation of osteoblasts. FASEB J. 2019 May 8:fj201802322RR.} {IF} {Mouse}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
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