SERPINB2 is also known as PAI or PAI2. Plasminogen activator inhibitor-2 (placental PAI) is acoagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form. It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosisduring pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.
[list_product_images]Western blot analysis of PAI-2 expression in HeLa whole cell lysates. PAI-2 at 42KD was detected using rabbit anti-Plasminogen Activator Inhibitor 2 Antigen Affinity purified polyclonal antibody (Catalog # A03427) at 1:500. Personal communication, Luca D'Agostino, Temple University, Philadelphia, PA.|PAI-2 was detected in paraffin-embedded sections of human heart tissue using rabbit anti-Plasminogen Activator Inhibitor 2 Antigen Affinity purified polyclonal antibody (Catalog # A03427) at 10ug/mL.[/list_product_images]