Synthesized peptide derived from internal of human CDK5R1.
内容
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
纯化方式
Immunogen affinity purified
浓度
500 ug/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
产品形态
Liquid
保存条件
12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料
CDK5R1 is also known as p35, CDK5R or NCK5A. The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
研究类别
1. Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.Engmann O, et al. Brain, 2011 Aug.2. Cdk5/p35 is required for motor coordination and cerebellar plasticity.He X, et al. J Neurochem, 2014 Oct.3. CDK5 and its activator P35 in normal pituitary and in pituitary adenomas: relationship to VEGF expression.Xie W, et al. Int J Biol Sci, 2014.
[list_product_images]Western blot analysis of extracts from rat brain cells, using CDK5R1 antibody A02595.|Immunofluorescence analysis of HeLa cells, using CDK5R1 antibody A02595.[/list_product_images]