Collagen type III occurs in most soft connective tissuesalong with type I collagen. Involved in regulation of corticaldevelopment. Is the major ligand of GPR56 in the developing brainand binding to GPR56 inhibits neuronal migration and activates theRhoA pathway by coupling GPR56 to GNA13 and possibly GNA12.
Collagen type III, also known as COL3A1, is assigned to chromosome 2. Ultrastructural analysis of tissues from mutant mice revealed that type III collagen is essential for normal collagen I fibrillogenesis in the cardiovascular system and other organs. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development.
[list_product_images]Western blot analysis of Collagen Type III expression in human Collagen III protein. Collagen Type III at 138KD was detected using rabbit anti-Collagen Type III polyclonal antibody (Catalog # A00788) at 1:1000.|Collagen Type III was detected in paraffin-embedded sections of right lobe of the liver using rabbit anti-Collagen Type III polyclonal antibody (Catalog # A00788) at 1:500. A: Central Vein (CV) fibrosis, B: Non-fibrotic CV, C: Perisinusodial fibrosis, D: Non-fibrotic area, E: Protat tract fibrosis, F: Septal fibrosis (arrow). The immunohistochemical section was developed using SABC method (Catalog # SA1022).|Collagen Type III was detected in paraffin-embedded sections of human intetsinal skin tissue (left) and human testis tissue (right) using rabbit anti-Collagen Type III polyclonal antibody (Catalog # A00788) at 1:400. Images provided courtesy of LifeSpan Biosciences, Seattle, WA.[/list_product_images]