Synthetic peptide corresponding to a portion of human FADD.
内容
Each vial contains 50% glycerol and 0.09% sodium azide.
纯化方式
Peptide affinity purified.
浓度
500 ug/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
产品形态
Liquid
保存条件
12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料
FADD, Fas-Associated protein with Death Domain, is a universal adaptor protein in apoptosis that mediates signaling of all known death domain-containing members of the TNF receptor superfamily. The FADD gene contains 2 exons and spans approximately 3.6 kb. By analysis of somatic cell hybrid panels and by fluorescence in situ hybridization, the FADD gene is mapped to 11q13.3. The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, thus, it participates in the death signaling initiated by these receptors.
[list_product_images]Western blot analysis of FADD expression in MW marker (lane 1) and HELA whole cell lysates (lane 2). FADD at 28KD was detected using rabbit anti- FADD Antigen Affinity purified polyclonal antibody (Catalog # A00237) at 1:1000. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002).|FADD was detected in paraffin-embedded sections of human kidney tissues using rabbit anti- FADD Antigen Affinity purified polyclonal antibody (Catalog # A00237) at 10 μg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022).|FADD was detected in paraffin-embedded sections of human placenta tissues using rabbit anti- FADD Antigen Affinity purified polyclonal antibody (Catalog # A00237) at 10 μg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022).[/list_product_images]