Signal transducer and activator of transcription 2
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Signal transducer and activator of transcription thatmediates signaling by type I IFNs (IFN-alpha and IFN-beta).Following type I IFN binding to cell surface receptors, Jakkinases (TYK2 and JAK1) are activated, leading to tyrosinephosphorylation of STAT1 and STAT2. The phosphorylated STATsdimerize, associate with IRF9/ISGF3G to form a complex termedISGF3 transcription factor, that enters the nucleus. ISGF3 bindsto the IFN stimulated response element (ISRE) to activate thetranscription of interferon stimulated genes, which drive the cellin an antiviral state..
Signal transducer and activator of transcription 2(STAT2) is a protein that in humans is encoded by the STAT2 gene. The protein encoded by this gene is a member of the STAT protein family. The International Radiation Hybrid Mapping Consortium mapped the STAT2 gene to chromosome 12. STAT2 is a transcription factor critical to the signal transduction pathway of type I interferons. ISGF3(STAT2) assembly involves p48 functioning as an adaptor protein to recruit Stat1 and Stat2 to an IFN-alpha-stimulated response element, Stat2 contributes a potent transactivation domain but is unable to directly contact DNA, while Stat1 stabilizes the heteromeric complex by contacting DNA directly.
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[list_product_images]Western blot analysis of Stat2pY690 protein expression in Jurkat cells without (left lane) and with (right lane) 1000U/mL of IFN-a for 15 min at 37u. Stat2pY690 at 113KD was detected using rabbit anti-STAT2 pY690 Antigen Affinity purified polyclonal antibody (Catalog # P01360) at 1:1000. Personal Communication, A.Gamero, NCI, Bethesda, MD. [/list_product_images]