VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. It may be a major regulator of tumor angiogenesis in vivo. Vascular endothelial growth factor is a mitogen primarily for vascular endothelial cells. It is, however, structurally related to platelet-derived growth factor. VEGF shares homology with the PDGF A chain and B chain, including conservation of all 8 cysteines found in PDGFA and PDGFB. VEGF gene contains 8 exons. Vascular endothelial growth factor(VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Vascular endothelial growth factor(VEGF) stimulates neurogenesis in vitro and in vivo.
[list_product_images]Western blot analysis of VEGF expression in VEGF-165 Recombinant Protein 50 ng (lane 1). VEGF at 22KD was detected using rabbit anti- VEGF Biotin Conjugated antibody (Catalog # B00045) at 1:1000. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002).[/list_product_images]