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文献和实验Genetic evidence strongly suggested that a tumor suppressor was located on chromosome 10. During the development of glioblastoma, one copy of chromosome 10 was typically lost (1 ). Cytogenetic and molecular analysis revealed partial
相关专题 细胞凋亡专题 PTEN依赖的细胞生长抑制和细胞凋亡 PTEN (phosphatase and tensin homology deleted on chromosome 10),在广泛的人类肿瘤中发生基因突变 或缺失。PTEN是一个PIP3-磷酸酶，与PI3K的功能相反，它可以通过去磷酸化将PIP3转变为PI-4,5-P2。PTEN可减少AKT的活化而阻止所有由AKT调控的下游信号传导事件
Measurement of PTEN Activity in vivo by Imaging Phosphorylated Akt
This chapter describes an indirect approach to measure PTEN’s lipid phosphatase activity in vivo . PTEN counteracts phosphatidylinositol 3-kinase action in dephosphorylating 3-phosphorylated phosphoinositides. Therefore, PtdIns(3,4,5)P3
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