Mouse Zinc Finger Homeobox Pro

人工转录因子的部件――人类锌指结构

. For example, novel DNA-binding proteins have been created by using phage display to alter the DNA-binding specificity of a zinc-finger protein (ZFP)2-7 . Although phage display is an effective method, it is labor-intensive and time-consuming

利用人工组合转录因子对人类基因组扫描

specificity of each fusion protein was tested by ELISA using a panel of DNA substrates (Fig. 2B,C). The predicted DNA binding site of each TFZF was decoded from the -helical sequence of the corresponding zinc finger (Table 1). As expected, the majority

v468 chapter 5 糖原合成酶激酶-3 的抑制

, axin, and the tumor suppressor, adenomatouspolyposis coli (APC) protein (3) . In the absence of Wnt signaling,GSK-3 targets b-catenin for ubiquitin-mediated proteosomaldegradation by phosphorylation of b-catenin, axin, and APC (3) . Phosphorylation