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- 2025年07月14日
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文献和实验Developing Genetically Engineered Mouse Models to Study Tumor Suppression
. Li, D.M. and Sun, H. 1997. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res. 57:2124‐2129
Several critical polypeptide growth factors have been identified for the lung, including transforming growth factor-beta (TGF-β). The three mammalian TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3, are homologous growth mediators
Use of RNA Interference to Investigate Cytokine Signal Transduction in Pancreatic Beta Cells
to the cytokines interleukin(IL)-1β + interferon(IFN)-γ or to tumor necrosis factor(TNF)-α + IFN-γ induces beta cell dysfunction and ultimately apoptosis. The transcription factors NF-κB and STAT1 are key regulators of cytokine-induced beta cell death
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