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文献和实验v468.Chapter 3 分泌型跨膜相关蛋白提纯及Wnt抑制活性
with the Wnt preparation and cellular context. Key words: sFRP , Recombinant expression , Protein purification , Heparin chromatography , Chelating chromatography , Wnt 1. Introduction Secreted Frizzled-related proteins (sFRPs) contain a Frizzled(Fzd
v468.chapter 1 经典 Wnt/b-Catenin 信号通路 （英文完整版）
-1 a proto-oncogene) and revealed Wnt-1to be a secreted cysteine-rich protein with the potential to act asa signalling molecule. However, the real breakthrough in linking thisgene to a signalling pathway was made by fly geneticists, who demonstrated
by a mechanism related to RNAi and PTGS. Although the rde-2 gene product has not yet been identified, the mut-7 gene encodes a protein with homology to the nuclease domains of RNase D and a protein implicated in Werner syndrome (a rapid aging disease) in humans
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