Human Permeability Glycoprotei

Screening for P-Glycoprotein (Pgp) Substrates and Inhibitors

P-glycoprotein (P-gp), the product of the human ABCB1 gene and often called MDR1, is the best understood membrane protein known to be involved in the active transport of drugs across biological membranes. In addition to mediating or limiting

Measurement of P-glycoprotein Function

The MDR 1-encoded P-glycoprotein (Pgp), when overexpressed in tumor cells, confers resistance to many clinically important classes of anticancer drugs. This phenomenon is called multidrug resistance (MDR). The finding that this gene

微型双功能抗体抗CD3/抗Pgp的构建和表达

类细胞为效应细胞来构建双特异抗体更为常见：第一.T细胞群中存在着免疫记忆细胞；第二.有证据表明在恶性肿瘤患者体内存在着肿瘤特异性的T细胞；第三.体内外实验表明抗CD3抗体激活的杀伤细胞（CD3AK）比IL-2激活的杀伤细胞（LAK）具有更强大的细胞毒效应[2]。体内外生物学实验结果表明：Diabody能同时与T细胞和癌细胞结合，并通过激活T细胞，来靶向杀灭癌细胞[3，4]。HIT3a[5]和PHMA02[6]是我所研制的鼠源性抗CD3和抗Pgp（P-glycoprotein）单克隆抗体，我们在克隆单克