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文献和实验The determination of the protein content of urokinase-type plasminogen activator (uPA) and its inhibitor, PAI-1, in breast cancer tissue extracts is used clinically to identify patients at risk to experience disease recurrence (metastasis
Parkinsons Disease: Assays for the Ubiquitin Ligase Activity of Neural Parkin
The identification of monogenic variants of Parkinson’s disease (PD) has provided novel insights into its unknown pathogenesis. As the first protein linked to autosomal-recessive forms of PD, Parkin became a welcome tool to explain
-synuclein, mimicking its effects in Parkinson’s disease. These data illustrate that the human gene coding for α-synuclein can be expressed in the fly and produce behavioral effects in accord with behaviors seen in patients with Parkinson’s disease.
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