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- EKU05617
- 2025年07月11日
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文献和实验Acute myeloid leukemia (AML) has an annual incidence of 2.4 cases per 100,000 persons and is the most common form of acute leukemia in adults (1 , 2 ). AML is a model for drug-resistant human cancers, and current therapies for AML possess
The IGF-1 receptor (IGF-1-R) belongs to the tyrosine kinase growth factor receptor family. It is structurally similar to, but distinct from, the insulin receptor, with which it shares a 70% homology. As expected, it crossreacts with insulin
NF-κB transcription factors marshal innate and adaptive immunity and inflammation. NF-κB also counters programmed cell death (PCD) induced by the proinflammatory cytokine tumor necrosis factor (TNF)α, and this activity of NF-κB is crucial
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