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文献和实验Identification, Characterization, and Differentiation of Human Prostate Cells
cells that express prostatespecific antigen (PSA; ref. 3 –7 ), cytokeratins 8 and 18 (8 ,9 ), and the nuclear androgen receptor (AR; ref. 2 and 10 ). In contrast to luminal epithelial cells, basal epithelial cells do not express PSA and AR
Animal Models of Prostate Cancer
prostate-specific antigen (PSA), and prostate specific membrane antigen (PSMA) and, with time, metastasizes to lymph nodes, bone, and other organs; it progresses to an androgen-independent (AI) state. Prostate cancer rarely arises spontaneously in animals
DNA Vaccination for Prostate Cancer
DNA-based cancer vaccines have been used successfully in mice to induce cytotoxic T lymphocytes (CTLs) specific for prostate antigens. Translation of a prostate-specific antigen (PSA) DNA vaccine into a phase I clinical trial demonstrated
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