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- 2025年07月16日
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文献和实验Characterization of Dopamine Receptors
of the radioligand's molar concentration is also included. Keywords: Receptor binding; dopamine; D1; D2; D3; D4; D5; radioligand binding GO TO THE FULL PROTOCOL:
In mammals, dopamine G protein-coupled receptors (GPCR) are segregated into two categories: D1-like (D1R and D5R) and D2-like (D2Rshort , D2Rlong , D3R, and D4R) subtypes. D1R and D5R are primarily coupled to stimulatory heterotrimeric GTP
. Two of them, the serotonin transporter knockout (SERT−/− ) rat and the dopamine D1 receptor mutant (DRD1−/− ) rat, are described in relation to four important (neurodevelopmental) psychiatric disorders: depression, autism, schizophrenia and drug addiction. It has been shown
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