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文献和实验Antigen-presenting dendritic cells (DCs) originate from hematopoietic stem cells in bone marrow through successive steps of differentiation (1 -5 ). In peripheral tissues (e.g., skin), DCs are exposed to and capture antigens like viruses
of multipotent CD34+ CD45+ hematopoietic progenitors via employing hEB hematopoietic differentiation followed by adherent hemogenic endothelium generation. Multipotent hematopoietic progenitors can be reproducibly generated in robust amounts
Human mast cells (HMCs) are derived from a CD34+ pluripotent progenitor cell that is Kit (CD117+), CD13+, FcεRI- and lacks lineage-specific surface markers. Bone marrow and peripheral blood are two tissue sources available for obtaining CD34
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