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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Proanthocyanidin B2
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
29106-49-8
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1485.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥430.0 |
| 规格： | 5 mg | 产品价格： | ￥1350.0 |
| 规格： | 10 mg | 产品价格： | ￥2300.0 |
| 规格： | 25 mg | 产品价格： | ￥4500.0 |
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Procyanidin B2
CAS No. : 29106-49-8
MCE 国际站：Procyanidin B2
产品活性：Procyanidin B2 是一种天然黄酮类物质，具有抗肿瘤，抗氧化等作用。
研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
In Vitro: Procyanidin B2 shows antiproliferative activity to MCF-7 cells, with an IC50 of 19.21 μM. However, Procyanidin B2 exhibits no effect on DNA-ladder formation. Procyanidin B2 (0.1, 1, 2 μM) inhibits the activation of pyrin domain containing 3 (NLRP3) inflammasome in human umbilical vein ECs (HUVECs), and the inhibition is via suppression of AP-1 activity, and such effect can be abolished by overexpression of c-Jun. Procyanidin B2 (2 μM for 12 h) also reduces ROS in HUVECs.
In Vivo: Procyanidin B2 (40, 20, and 10 mg/kg, p.o.) protects against cerebral ischemia-induced infarct volume and brain edema in rats. Procyanidin B2 (40 mg/kg, p.o) also improves functional outcomes, regulates blood-brain barrier (BBB) permeability after cerebral ischemia. Moreover, Procyanidin B2 attenuates cerebral ischemia-induced tight junction degradation, mitochondrial depolarization and intracellular oxidative stress. Procyanidin B2 (40 mg/kg, p.o) increases Nrf2 activation and HO-1, GSTα, and NQO1 protein expression in normal brains in vivo.
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文献和实验Studying the Treatment of Chronic Hepatitis B Viral Infection in Special Populations
There are estimated to be more than 400 million people chronically infected with the hepatitis B virus (HBV) worldwide (Fig. 1 ) ( 1 ). At least 20–30% of those chronically infected will die of complications of chronic liver disease including
Gz-B 诱发细胞凋亡涉及的四种机制 1)直接裂解胱天蛋白酶3前酶(pro-caspase 3)或间接裂解pro-caspase 8而启动细胞凋亡(有关胱天蛋白酶及其前酶裂解的内容详后)。现知Gz-B可以裂解caspase前酶序列中的Ile／Val-Gly／Met／Glu-x-Asp-x-Gly(x代表任意氨基酸)，因此具有广泛的caspase活化作用。 2)通过裂解BID而引起Bcl-2家族分子如Bax转位至线粒体，引起细胞色素c释放
【求助】一句英文怎么翻译？涉及TGFβ-b诱导乙酰化的Foxp3 。谢谢！
dahaixiaodao 关于组蛋白去乙酰化酶HDACs在Tregs的发育和功能。 谢谢！ TGFβ-b induces chromatin binding and promoter occupancy of acetylated Foxp3 on the IL-2 promoter. zhujoker 这句话的大概意思是 TGFβ-b诱导乙酰化的Foxp3结合于染色体上从而占用了启动子结合区
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