Molecular Toxicology Pathway F

分子毒理通路发现者基因表达PCR芯片可用于研究与13个被药物毒性激活的生物学通路中的370个关键基因的表达。在药物处理后的细胞系或组织（肝脏）中进行这些基因的表达情况的检测，可以找到该药物诱导的毒理反应，包括编码电子转运链以及氧化磷酸化复合物组成蛋白的基因。利用该芯片，研究者可以方便并且可信地对药物的毒理反应通路相关的基因进行同时检测。
Apoptosis: ABL1, AKT1, APAF1, BAD, BAK1, BAX, BCL2, BCL2L1 (BCL-X), BCL2L11, BID, BIRC3 (c-IAP1), CASP1 (ICE), CASP3, CASP7, CASP8 (FLICE), CASP9, CD40 (TNFRSF5), CD40LG (TNFSF5), CFLAR (CASPER), FADD, FAS (TNFRSF6), FASLG (TNFSF6), GADD45A, MCL1, TNF, TNFRSF10A, TNFRSF10B (DR5), TNFRSF1A, TNFSF10 (TRAIL), TP53, XIAP.
Necrosis: ATP6V1G2, BMF, CCDC103, CD300LD, CLEC18A, COMMD4, CYLD, DEFB1, DPYSL4, EIF5B, FOXI1, GALNT5, GRB2, HOXA3, HSPBAP1, JPH3, KCNIP1, MAG, NUDT13, OR10J3, PARP2, PVR, RAB25, S100A7A, SPATA2, SYCP2, TMEM57, TNFAIP8L1, TNFRSF1A, TXNL4B.
DNA Damage & RePAir: APEX1, ATM, ATR, BRCA1, BRCA2, CDKN1A (p21CIP1/WAF1), CHEK1, CHEK2 (RAD53), DDIT3 (GADD153/CHOP), ERCC1, ERCC2 (XPD), ERCC3 (XPB), ERCC5, ERCC6, GADD45A, LIG4, MDM2, MGMT (AGT), MLH1, MSH2, OGG1, PARP1 (ADPRT1), PCNA, PRKDC, RAD51, TP53, XPA, XPC, XRCC1, XRCC5.
Mitochondrial Energy Metabolism: ACLY, ACO1, ACO2, COX6B1, COX8A, CS, CYC1, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH1B, MDH2, OGDH, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, UCP1, UCP2, UCP3.
Fatty Acid Metabolism (ß-Oxidation): ACAA1, ACAA2, ACAD11, ACAD9, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOT1, ACOT12, ACOT6, ACOT7, ACOT8, ACOT9, ACOX1, ACOX2, ACOX3, BDH2, CPT1A, CPT1B, CPT2, C, CROT, DECR1, ECHS1, EHHADH, GCDH, HADHA.
Oxidative Stress & Antioxidant Response: AASS, CAT, CTSB, DHCR24, DUOX1, DUOX2, EPX, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, IDH1, MPO, NQO1, NUDT1, NUDT15, PPP1R15B, PRDX1, PRDX2, PRDX6 (AOP2), SOD1, TPO, TXNIP, TXNRD2, UCP3.
Heat Shock Response: CRYAA, CRYAB, DNAJA1, DNAJA2, DNAJA3, DNAJB1, DNAJB6, DNAJC3, DNAJC5, DNAJC6, HSF1 (TCF5), HSF2, HSP90AA1, HSP90AB1, HSP90B1 (TRA1), HSPA1A, HSPA1B, HSPA1L, HSPA2, HSPA4 (HSP70), HSPA5 (GRP78), HSPA8, HSPA9, HSPB1 (HSP27), HSPB2, HSPB6, HSPB8, HSPD1, HSPE1, HSPH1 (HSP105), TCP1.
ER Stress & Unfolded Protein Response: AMFR, ATF4, ATF6, BAX, DDIT3, DERL1, EDEM1, EDEM3, EIF2AK3, ERN2, ERO1L, ERO1LB, FBXO6, GADD45A, HERPUD1, HTRA2, HTRA4, MBTPS1, MBTPS2, NPLOC4, NUCB1, OS9, PFDN5, SEC62, SEL1L, SELS, SERP1, SYVN1, UBE2G2, UBE2J2, UBXN4, VCP, XBP1.
Cytochrome P450s & Phase I Drug Metabolism: CYP1A1, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, ESD, FMO2, FMO3, FMO4, FMO5, MAOA, MAOB.
Steatosis: ACACA, ADK, ALDH2, AQP4, CD36, COMT, CYP2E1, CYP7B1, DNM1, ENO1, FAS, FASN, GPD1, HAAO, HADHB, KHK, LMNA, LPL, LY6D, MAPK8 (JNK1), MTTP, PCCA, PNPLA3, PPARA, RETN, SCD, SREBF1, SYT1, TFF3, VCP.
Cholestasis: ABCB1, ABCB4, ABCC1 (MRP1), ABCC2 (MRP2), ABCC3 (MRP3), APOE, ATP8B1, CYP3A4, CYP7A1, DLAT, ESR1 (ERa), HLA-DRB1, ICAM1, IL10, IL1B, IL2, IL6, JAG1, MPO, NR1H4, NUP210, OSTALPHA, OSTBETA, PDYN, RDX, SLC10A1, TGFB1, TNF.
Phospholipidosis: ABCB1 (MDR1), ALDH1A1, ASAH1, ASNS, CES2, CTSB, EPHX1, FABP1, FXC1 (TIMM10B), GSTM4, HPN, INHBE, LSS, MANBA, MLX, MRPS18B, NR0B2, POR, S100A8, SC4MOL, SERPINA3, SLC2A3, SLCO1A2, SMPD1, STBD1, TAGLN, UGT1A1, UGT2A1, UGT2B4, WIPI1.
Immunotoxicity: ADH1C, AHR, AHSG, ALB, APOA5, APOF, C3, C9, CASP3, CD19, CD4, CD44, CD80, CD86, CD8A, CTSE, CYP1A1, CYP3A4, CYP3A4, EP300, F2, FABP1, FAS, GPT, GSTA3, HPX, HRG, HSPA5, IFNA1, IFNG, IL10, IL13, IL1A, IL1B, IL2, IL4, IL5, IL6, ITGAX, KLF1, LYZ, LYZ, METAP2, MKI67, NFKB1, NR5A2, PON1, POU3F3, PTGS2 (COX2), PTPRC, SOD1, TNF, TRIM10, UBQLN2.