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Apoptosis: ABL1, AKT1, APAF1, BAD, BAK1, BAX, BCL2, BCL2L1 (BCL-X), BCL2L11, BID, BIRC3 (c-IAP1), CASP1 (ICE), CASP3, CASP7, CASP8 (FLICE), CASP9, CD40 (TNFRSF5), CD40LG (TNFSF5), CFLAR (CASPER), FADD, FAS (TNFRSF6), FASLG (TNFSF6), GADD45A, MCL1, TNF, TNFRSF10A, TNFRSF10B (DR5), TNFRSF1A, TNFSF10 (TRAIL), TP53, XIAP.
Necrosis: ATP6V1G2, BMF, CCDC103, CD300LD, CLEC18A, COMMD4, CYLD, DEFB1, DPYSL4, EIF5B, FOXI1, GALNT5, GRB2, HOXA3, HSPBAP1, JPH3, KCNIP1, MAG, NUDT13, OR10J3, PARP2, PVR, RAB25, S100A7A, SPATA2, SYCP2, TMEM57, TNFAIP8L1, TNFRSF1A, TXNL4B.
DNA Damage & RePAir: APEX1, ATM, ATR, BRCA1, BRCA2, CDKN1A (p21CIP1/WAF1), CHEK1, CHEK2 (RAD53), DDIT3 (GADD153/CHOP), ERCC1, ERCC2 (XPD), ERCC3 (XPB), ERCC5, ERCC6, GADD45A, LIG4, MDM2, MGMT (AGT), MLH1, MSH2, OGG1, PARP1 (ADPRT1), PCNA, PRKDC, RAD51, TP53, XPA, XPC, XRCC1, XRCC5.
Mitochondrial Energy Metabolism: ACLY, ACO1, ACO2, COX6B1, COX8A, CS, CYC1, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH1B, MDH2, OGDH, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, UCP1, UCP2, UCP3.
Fatty Acid Metabolism (ß-Oxidation): ACAA1, ACAA2, ACAD11, ACAD9, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOT1, ACOT12, ACOT6, ACOT7, ACOT8, ACOT9, ACOX1, ACOX2, ACOX3, BDH2, CPT1A, CPT1B, CPT2, C, CROT, DECR1, ECHS1, EHHADH, GCDH, HADHA.
Oxidative Stress & Antioxidant Response: AASS, CAT, CTSB, DHCR24, DUOX1, DUOX2, EPX, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, IDH1, MPO, NQO1, NUDT1, NUDT15, PPP1R15B, PRDX1, PRDX2, PRDX6 (AOP2), SOD1, TPO, TXNIP, TXNRD2, UCP3.
Heat Shock Response: CRYAA, CRYAB, DNAJA1, DNAJA2, DNAJA3, DNAJB1, DNAJB6, DNAJC3, DNAJC5, DNAJC6, HSF1 (TCF5), HSF2, HSP90AA1, HSP90AB1, HSP90B1 (TRA1), HSPA1A, HSPA1B, HSPA1L, HSPA2, HSPA4 (HSP70), HSPA5 (GRP78), HSPA8, HSPA9, HSPB1 (HSP27), HSPB2, HSPB6, HSPB8, HSPD1, HSPE1, HSPH1 (HSP105), TCP1.
ER Stress & Unfolded Protein Response: AMFR, ATF4, ATF6, BAX, DDIT3, DERL1, EDEM1, EDEM3, EIF2AK3, ERN2, ERO1L, ERO1LB, FBXO6, GADD45A, HERPUD1, HTRA2, HTRA4, MBTPS1, MBTPS2, NPLOC4, NUCB1, OS9, PFDN5, SEC62, SEL1L, SELS, SERP1, SYVN1, UBE2G2, UBE2J2, UBXN4, VCP, XBP1.
Cytochrome P450s & Phase I Drug Metabolism: CYP1A1, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, ESD, FMO2, FMO3, FMO4, FMO5, MAOA, MAOB.
Steatosis: ACACA, ADK, ALDH2, AQP4, CD36, COMT, CYP2E1, CYP7B1, DNM1, ENO1, FAS, FASN, GPD1, HAAO, HADHB, KHK, LMNA, LPL, LY6D, MAPK8 (JNK1), MTTP, PCCA, PNPLA3, PPARA, RETN, SCD, SREBF1, SYT1, TFF3, VCP.
Cholestasis: ABCB1, ABCB4, ABCC1 (MRP1), ABCC2 (MRP2), ABCC3 (MRP3), APOE, ATP8B1, CYP3A4, CYP7A1, DLAT, ESR1 (ERa), HLA-DRB1, ICAM1, IL10, IL1B, IL2, IL6, JAG1, MPO, NR1H4, NUP210, OSTALPHA, OSTBETA, PDYN, RDX, SLC10A1, TGFB1, TNF.
Phospholipidosis: ABCB1 (MDR1), ALDH1A1, ASAH1, ASNS, CES2, CTSB, EPHX1, FABP1, FXC1 (TIMM10B), GSTM4, HPN, INHBE, LSS, MANBA, MLX, MRPS18B, NR0B2, POR, S100A8, SC4MOL, SERPINA3, SLC2A3, SLCO1A2, SMPD1, STBD1, TAGLN, UGT1A1, UGT2A1, UGT2B4, WIPI1.
Immunotoxicity: ADH1C, AHR, AHSG, ALB, APOA5, APOF, C3, C9, CASP3, CD19, CD4, CD44, CD80, CD86, CD8A, CTSE, CYP1A1, CYP3A4, CYP3A4, EP300, F2, FABP1, FAS, GPT, GSTA3, HPX, HRG, HSPA5, IFNA1, IFNG, IL10, IL13, IL1A, IL1B, IL2, IL4, IL5, IL6, ITGAX, KLF1, LYZ, LYZ, METAP2, MKI67, NFKB1, NR5A2, PON1, POU3F3, PTGS2 (COX2), PTPRC, SOD1, TNF, TRIM10, UBQLN2.
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文献和实验PCR芯片，研究者可以同时研究大量基因，既可以进行某些特别感兴趣的信号通路的研究，也可以作为验证芯片结果的方法。 为了获得理想的实验结果，PCR芯片面临以下挑战：高特异性，高灵敏度和可重复性。高灵敏度或低检出限，在样品的总RNA量少，基因表达量低的情况下，也能检测出目的基因。高特异性，扩增产物严格保证基因特异性，避免非特异性产物，如引物二聚体的产生。可重复性，通过标准化的反应体系和实验方法，使得多人多次重复实验均能获得可靠的基因定量结果。 PCR芯片实验操作步骤 采用PCR芯片进行实验只需
DNA Microarrays: An Overview of Technologies and Applications to Toxicology
to simultaneously monitor the expression levels and/or genotypes of thousands of genes. The application of these techniques heralds a new era in toxicology research, where genotypes and toxicant?induced expression signatures may be used to monitor cellular responses
Finder）基因芯片，用于帮助研究人员在信号转导途径这一异常复杂的生物学网络中探索遨游。其中有一种信号转导通路发现者芯片(Signal Transduction Pathway Finder Gene Array 货号;HS-008)可以同时监测18条信号通路。例如：为了探测MAP30（一种抗HIV的试剂）对AIDS相关的淋巴瘤细胞的基因表达的影响，S.Lee-Hung等研究人员选用了SuperArray公司的一个与8个信号通路有关的通路发现者基因芯片。通过这个芯片的检测，他们很快发现其中三个信号通路
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