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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
2'-Deoxy-5-fluorocytidine
- 规格：
50mg
Aliases: 2'-Deoxy-5-fluorocytidine, 5-Fluoro-2'-deoxycytidine; FCDR; FdCyd; NSC-48006
Application: DNMT inhibitor
MW = 245.2
C9H12FN3O4
CAS 10356-76-0
MP = 196°C
>98% (TLC); NMR (Conforms)
A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors (ref 1). Like 5-Azacytidine and decitabine, 2'-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation (ref 2). It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways (ref 3). It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo (ref 4).
White solid. May be dissolved in DMSO (20 mg/ml).
1. J Ren et al. Cell Signal. 2011, 23:1082
2. H Gowher et al. Cancer Biol. Ther. 2004, 3:1062
3. Q Zhao et al. Springerplus 2002, 1:65
4. Y Kumaki et al. Antiviral Res. 2011, 92:329
其他 DNMT抑制剂
5-Aza-2’-deoxycytidine (Decitabine) DNMT inhibitor
5-Azacytidine DNMT inhibitor
6-Thioguanine DNMT inhibitor
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文献和实验1a).Part II Triple immunoprecipitation: H3K27 ChIP/-flag-DNMT3A/biotin-RNA A total of 4.0×106 293T cells are plated out and 24 hours later transfected plated (~70% confluent at the time of transfection) with the flag-tagged protein expressing plasmid
药物疗法小得多，从这方面讲，这种疗法的前景十分诱人，尽管整体甲基化不足也有副作用。抗DNA甲基化治疗有几个途径：第一、药物治疗。至今只有几种有效的DNMT抑制剂。如5-氮杂胞苷（5-azacytidine）和2-脱氧-5-氮杂胞苷（亦称decitabine），已用于抑制培养细胞的DNA甲基化，显示能激活被甲基化失活的基因。另decitabine还能诱导细胞分化，用于治疗造血紊乱。但因其毒性，它在重激活被甲基化灭活的基因方面的应用受到一定限制。组蛋白去乙酰酶活性在甲基化基因的转录抑制也起重要作用
(Figure 1a). Part II Triple immunoprecipitation: H3K27 ChIP/-flag-DNMT3A/biotin-RNA A total of 4.0×106 293T cells are plated out and 24 hours later transfected plated (~70% confluent at the time of transfection) with the flag-tagged protein
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