文献支持

Suramin sodium salt是一种可逆的竞争性蛋白

酪氨酸磷酸酶 (PTPases) 抑制剂。

价格￥550

品牌medchemexpress(MCE)
产地美国
货号HY-B0879A
更新日期2025年07月11日

杭州昊鑫生物科技股份有限公司

11 年钻石会员

Suramin sodium salt (Synonyms: 苏拉明钠; Suramin hexasodium salt)
Suramin sodium salt (Suramin hexasodium salt) 是一种可逆的竞争性蛋白酪氨酸磷酸酶 (PTPases) 抑制剂。Suramin sodium salt 是有效的 sirtuins 抑制剂：SirT1 (IC₅₀=297 nM)，SirT2 (IC₅₀=1.15 μM)，SirT5 (IC₅₀=22 μM)。Suramin sodium salt 是竞争性逆转录酶抑制剂 (DNA topoisomerase II: IC₅₀=5 μM)。S

美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司

MCE中国是全球领先的科研化学品和生物活性化合物供应商，总部位于美国新泽西。我们的产品范围覆盖各种抑制剂、激动剂、API和化合物库。专业、高效的企业灵魂铸造了在行业的卓越地位。热情和充满活力的研发团队拥有着大量的化学和生物科学家。专注于生物活性化合物，拥有着多年的发展历程和丰富的行业经验。从产品的HNMR数据解析到生物活性数据，从客户的询价到产品的售后服务，我们拥有着完善的管理体系，从而保证我们的服务更加高效、准确。努力为中国的医药行业发展注入新的活力，我们将成为您研发工作值得信赖的伙伴。
产品细节图片2

生物活性

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases)inhibitor^[1]. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM)^[2]. Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM)^[3]^[4].

IC₅₀ & Target^[2]

SIRT1

297 nM (IC₅₀)

SIRT2

1.15 μM (IC₅₀)

SIRT5

22 μM (IC₅₀)

体外研究 (In Vitro)	Suramin sodium salt (Suramin hexasodium salt；50-600 μg/mL；for 24-96 hours) 以剂量依赖性和时间依赖性方式抑制细胞增殖并降低癌细胞的活力^[7]。 Suramin sodium salt (300 μg/mL；for 48 hours) 诱导细胞凋亡并下调HeLa细胞中的mRNA表达^[7]。 Suramin sodium salt (1 mg/mL；1 hour) 显著抑制磷酸化的 ERK1/2^[8]。抑制 HO-8910 PM 和 HeLa 的 IC₅₀ 值分别为 319 μg/mL、476 μg/mL^[7]。 Suramin sodium salt 阻断 Vero E6 细胞中的病毒复制^[5]。

体外研究
(In Vitro)

Suramin sodium salt (Suramin hexasodium salt；50-600 μg/mL；for 24-96 hours) 以剂量依赖性和时间依赖性方式抑制细胞增殖并降低癌细胞的活力^[7]。
Suramin sodium salt (300 μg/mL；for 48 hours) 诱导细胞凋亡并下调HeLa细胞中的mRNA表达^[7]。
Suramin sodium salt (1 mg/mL；1 hour) 显著抑制磷酸化的 ERK1/2^[8]。
抑制 HO-8910 PM 和 HeLa 的 IC₅₀ 值分别为 319 μg/mL、476 μg/mL^[7]。
Suramin sodium salt 阻断 Vero E6 细胞中的病毒复制^[5]。

体内研究 (In Vivo)	苏拉明钠盐 (苏拉明六钠盐；10 mg/kg；静脉注射；每周两次，持续 3 周) 可逆转已形成的肺动脉高压 (PH)，从而使肺动脉压力值和血管结构正常化^[8]。

分子量	1429.17
Formula	C₅₁H₃₄N₆Na₆O₂₃S₆
CAS 号	129-46-4
性状	固体
颜色	Off-white to light brown
中文名称	苏拉明钠
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献	[1]. Zhang YL, et al. Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases. J Biol Chem. 1998 May 15;273(20):12281-7. [Content Brief] [2]. Trapp J, et al. Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). ChemMedChem. 2007 Oct;2(10):1419-31. [Content Brief] [3]. Schuetz A, et al. Structural basis of inhibition of the human NAD⁺-dependent deacetylase SIRT5 by suramin. Structure. 2007 Mar;15(3):377-89. [Content Brief] [4]. De Clercq E, et al. Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses. Cancer Lett. 1979 Nov;8(1):9-22. [Content Brief] [6]. Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7. [Content Brief] [7]. Xiaozhe Zhang, et al. Suramin and NF449 Are IP5K Inhibitors That Disrupt IP6-mediated Regulation of Cullin RING Ligase and Sensitize Cancer Cells to MLN4924/pevonedistat. J Biol Chem. 2020 Jun 3;jbc.RA120.014375. [Content Brief] [8]. Novaes RD, et al. Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by EnhancingParasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice. Oxid Med Cell Longev. 2018 Sep 30;2018:7385639. [Content Brief] [9]. Izikki M, et al. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. PLoS One. 2013 Oct 15;8(10):e77073. [Content Brief]

参考文献

[1]. Zhang YL, et al. Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases. J Biol Chem. 1998 May 15;273(20):12281-7.  [Content Brief]

[2]. Trapp J, et al. Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). ChemMedChem. 2007 Oct;2(10):1419-31.  [Content Brief]

[3]. Schuetz A, et al. Structural basis of inhibition of the human NAD⁺-dependent deacetylase SIRT5 by suramin. Structure. 2007 Mar;15(3):377-89.  [Content Brief]

[4]. De Clercq E, et al. Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses. Cancer Lett. 1979 Nov;8(1):9-22.  [Content Brief]

[6]. Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7.  [Content Brief]

[7]. Xiaozhe Zhang, et al. Suramin and NF449 Are IP5K Inhibitors That Disrupt IP6-mediated Regulation of Cullin RING Ligase and Sensitize Cancer Cells to MLN4924/pevonedistat. J Biol Chem. 2020 Jun 3;jbc.RA120.014375.  [Content Brief]

[8]. Novaes RD, et al. Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by EnhancingParasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice. Oxid Med Cell Longev. 2018 Sep 30;2018:7385639.  [Content Brief]

[9]. Izikki M, et al. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. PLoS One. 2013 Oct 15;8(10):e77073.  [Content Brief]

风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。

文献和实验

该产品被引用文献

参考文献	[1]. Zhang YL, et al. Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases. J Biol Chem. 1998 May 15;273(20):12281-7. [Content Brief] [2]. Trapp J, et al. Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). ChemMedChem. 2007 Oct;2(10):1419-31. [Content Brief] [3]. Schuetz A, et al. Structural basis of inhibition of the human NAD⁺-dependent deacetylase SIRT5 by suramin. Structure. 2007 Mar;15(3):377-89. [Content Brief] [4]. De Clercq E, et al. Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses. Cancer Lett. 1979 Nov;8(1):9-22. [Content Brief] [6]. Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7. [Content Brief] [7]. Xiaozhe Zhang, et al. Suramin and NF449 Are IP5K Inhibitors That Disrupt IP6-mediated Regulation of Cullin RING Ligase and Sensitize Cancer Cells to MLN4924/pevonedistat. J Biol Chem. 2020 Jun 3;jbc.RA120.014375. [Content Brief] [8]. Novaes RD, et al. Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by EnhancingParasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice. Oxid Med Cell Longev. 2018 Sep 30;2018:7385639. [Content Brief] [9]. Izikki M, et al. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. PLoS One. 2013 Oct 15;8(10):e77073. [Content Brief]

参考文献

[1]. Zhang YL, et al. Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases. J Biol Chem. 1998 May 15;273(20):12281-7.  [Content Brief]

[2]. Trapp J, et al. Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). ChemMedChem. 2007 Oct;2(10):1419-31.  [Content Brief]

[3]. Schuetz A, et al. Structural basis of inhibition of the human NAD⁺-dependent deacetylase SIRT5 by suramin. Structure. 2007 Mar;15(3):377-89.  [Content Brief]

[4]. De Clercq E, et al. Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses. Cancer Lett. 1979 Nov;8(1):9-22.  [Content Brief]

[6]. Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7.  [Content Brief]

[7]. Xiaozhe Zhang, et al. Suramin and NF449 Are IP5K Inhibitors That Disrupt IP6-mediated Regulation of Cullin RING Ligase and Sensitize Cancer Cells to MLN4924/pevonedistat. J Biol Chem. 2020 Jun 3;jbc.RA120.014375.  [Content Brief]

[8]. Novaes RD, et al. Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by EnhancingParasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice. Oxid Med Cell Longev. 2018 Sep 30;2018:7385639.  [Content Brief]

[9]. Izikki M, et al. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. PLoS One. 2013 Oct 15;8(10):e77073.  [Content Brief]

大家都在搜

大家都在搜

Suramin sodium salt是一种可逆的竞争性蛋白

相关产品推荐更多 >

Miriplatin (SM-11355) 为有效的化疗剂，是烷化剂 (alkylator) 的一种。

LCL161是 IAP 的抑制剂，抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1 的 IC50 分别为 35 和 0.4 nM。

6-TAMRA-SE (6-TAMRA-NHS ester) 是一种带有胺反应基的荧光染料。6-TAMRA-SE 是用于 DNA 自动测序的传统荧光团之一。

RS102895 是一种有效的 CCR2 拮抗剂，IC50 值为 360 nM，对 CCR1 无作用。

AGN 196996是高活性RARα选择性抑制剂

万千商家帮你免费找货

0 人在求购买到急需产品

关于丁香通

公司信息

个人用户

企业机构

大家都在搜

大家都在搜

Suramin sodium salt是一种可逆的竞争性蛋白

相关产品推荐更多 >

Miriplatin (SM-11355) 为有效的化疗剂，是烷化剂 (alkylator) 的一种。

LCL161是 IAP 的抑制剂，抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1 的 IC50 分别为 35 和 0.4 nM。

6-TAMRA-SE (6-TAMRA-NHS ester) 是一种带有胺反应基的荧光染料。6-TAMRA-SE 是用于 DNA 自动测序的传统荧光团之一。

RS102895 是一种有效的 CCR2 拮抗剂，IC50 值为 360 nM，对 CCR1 无作用。

AGN 196996是高活性RARα选择性抑制剂

万千商家帮你免费找货

0 人在求购买到急需产品

同类产品报价

关于丁香通

公司信息

个人用户

企业机构