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详见说明
Thiamphenicol
充足
杭州昊鑫生物
15318-45-3
100mg
生物活性 | Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial Antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2]. |
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体外研究 (In Vitro) |
Thiamphenicol shows a significant post-antibiotic effect (PAE) (0.33 to 2.9h) on all pathogens studied (S. pneumoniae, S. aureus and Escherichia coli) and a powerful bactericidal effect against β-lactamase-positive and -negative H. influenzae. Thiamphenicol MICs for the microorganisms analyzed are: 32 mg/L (S. aureus and E. coli), 2 mg/L (S. pneumoniae) and 0.25 mg/L (H. influenzae). Thiamphenicol shows a good in vitro activity against difficult-to-treat multiply resistant pathogens[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
The pharmacokinetics of Thiamphenicol (30 mg/kg) after single intravenous (IV) and oral (PO) administration is investigated in Mulard ducks. After IV administration, for Thiamphenicol, the mean residence time is 2.83 hours, the general half-life is 1.96 hours, the clearance is 0.04 L/hr/kg. Pharmacokinetics after PO administration is very similar for IV administration. Thiamphenicol shows rapid absorption and bioavailability of more than 70%[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 | 356.22 |
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Formula | C12H15Cl2NO5S |
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CAS 号 | |||||||||||||||||
中文名称 | 甲砜霉素;甲砜氯霉素 |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL (280.73 mM; Need ultrasonic) H2O : 2 mg/mL (5.61 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百 |
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