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4°C
详见说明
Tetracycline hydrochloride
充足
杭州昊鑫生物
64-75-5
1g
生物活性 | Tetracycline (hydrochloride) is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria. |
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IC50 & Target |
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体外研究 (In Vitro) |
Tetracyclines are broad-spectrum agents, exhibiting activity against a wide range of gram-positive and gram-negative bacteria, atypical organisms such as chlamydiae, mycoplasmas, and rickettsiae, and protozoan parasites. Tetracyclines inhibit bacterial protein synthesis by preventing the association of aminoacyl-tRNA with the bacterial ribosome. Tetracyclines traverse the outer membrane of gram-negative enteric bacteria through the OmpF and OmpC porin channels, as positively charged cation (probably magnesium)-tetracycline coordination complexes [1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
The tetracyclines have applications for the treatment of infections in poultry, cattle, sheep, and swine. In some cases, e.g., for therapeutic treatment of large numbers of poultry reared on commercial farms, the antibiotics are added directly to feed or water or can be administered in aerosols. Tetracyclines could be used as growth promotion or growth enhancement. Tetracyclines are used in aquaculture to control infections in salmon, catfish, and lobsters[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 | 480.90 |
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Formula | C22H25ClN2O8 |
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CAS 号 | |||||||||||||||||
中文名称 | 盐酸四环素;盐酸托妥霉素 |
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结构分类 | |||||||||||||||||
来源 | Streptomyces |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
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储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 | In Vitro: DMSO : 62.5 mg/mL (129.96 mM; Need ultrasonic) H2O : 50 mg/mL (103.97 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百 |
参考文献 |
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