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详见说明
Temocapril
充足
杭州昊鑫生物
110221-44-8
10mg
生物活性 | Temocapril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases[1][2]. |
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IC50 & Target | ACE[1] |
体外研究 (In Vitro) |
Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 (human carboxylesterase 1) in the liver[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[3]
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体内研究 (In Vivo) |
Temocapril hydrochloride (10 mg/kg; p.o.; 21 d) enhances cardiomyocyte thioredoxin expression and ameliorates autoimmune myocarditis[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 | 513.07 |
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Formula | C23H29ClN2O5S2 |
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CAS 号 | |||||||||||||||||
中文名称 | 盐酸替莫普利 |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
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储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 | In Vitro: DMSO : 62.5 mg/mL (121.82 mM; ultrasonic and warming and heat to 60°C) H2O : 2.27 mg/mL (4.42 mM; ultrasonic and warming and heat to 60°C) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。 |
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参考文献 |
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