Chloramphenicol (氯霉素)

价格￥500

品牌medchemexpress(MCE)
产地美国
货号HY-B0239
更新日期2025年07月16日

11 年钻石会员

Chloramphenicol (Synonyms: 氯霉素)

Chloramphenicol 是一种口服有效的广谱抗生素 (antibiotic)。Chloramphenicol 具有抗菌 (antibacterial) 活性。Chloramphenicol 抑制缺氧 A549 和 H1299 细胞中氧不稳定转录因子和缺氧诱导因子-1α (HIF-1α)。Chloramphenicol 可抑制血管内皮生长因子 (VEGF) 和葡萄糖转运蛋白 1 (glucose transporter 1) 的 mRNA 水平，最终降低 VEGF 的释放。Chloramphenicol 可用于厌氧菌感染和肺癌研究。
产品细节图片1

美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
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生物活性

Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research^[1]^[2]^[3].

IC₅₀ & Target

JNK

MMP13

体外研究
(In Vitro)

Chloramphenicol (1-100 μg/mL, 18-24 h) inhibits the HIF-1α pathway in NSCLC cells in a concentration-dependent manner^[1].
Chloramphenicol (100 μg/mL, 0-24 h) induces autophagy in NSCLC cells, substantially increases the levels of autophagic biomarkers (beclin-1, Atg12-Atg5 conjugates, and LC3-II)^[1].
Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells^[2].
Chloramphenicol can inhibit both bacterial and mitochondrial protein synthesis, causing mitochondrial stress and decreased ATP biosynthesis^[3].
chloramphenicol (1-100 μg/mL) can induce matrix metalloproteinase (MMP)-13 expression and increase MMP-13 protein^[3].
chloramphenicol (1-100 μg/mL) can activate c-Jun N-terminal kinases (JNK) and phosphatidylinositol 3-kinase (PI-3K)/Akt signaling, leading to c-Jun protein phosphorylation^[3].
Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	A549 and H1299 cells
Concentration:	0, 1, 10, 100 μg/mL
Incubation Time:	3 h and 24 h
Result:	In the 3-h-treated group, the viability of A549 and H1299 cells at 100 μg/mL concentration was 97.0 ± 3.9% and 98.1 ± 5.0%, respectively. The viability of A549 cells was 102.9 ± 1.3% and 99.2 ± 0.9%, whereas the viability of H1299 cells was 103.3 ± 1.9% and 93.8 ± 4.5%, under hypoxia and treatment with CoCl2, respectively.

体内研究
(In Vivo)

Chloramphenicol (0-3500 mg/kg, Gavage, daily, for 5 days) decreases erythrocytes and erythrocyte precursors and reduces marrow erythroid cells were at day 1 post-dosing, and returns to normal by 14 days post-dosing^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female B6C3F1 mice (12-14 weeks old)^[4]
Dosage:	0, 2500 and 3500 mg/kg
Administration:	Gavage, daily, for 5 days
Result:	Cessation of erythropoiesis was evident at day 1 post-dosing. A recovery was seen at day 7 post-dosing at the 2500 mg/kg dose level and at between 7 and 14 days at the 3500 mg/kg dose level. Myelotoxicity was most pronounced in the erythroid series at each dose level. Depressed femoral marrow BFU-E and CFU-E at day 1 post-dosing. All the blood and marrow parameters in the present study returned to normal by 14 days post-dosing.

分子量

323.13

Formula

C₁₁H₁₂Cl₂N₂O₅

CAS 号

56-75-7

中文名称

氯霉素

结构分类

来源

Streptomyces venezuelae

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

In Vitro:

DMSO : ≥ 150 mg/mL (464.21 mM)

Ethanol : 100 mg/mL (309.47 mM; Need ultrasonic)

H₂O : 3.06 mg/mL (9.47 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0947 mL	15.4736 mL	30.9473 mL
5 mM	0.6189 mL	3.0947 mL	6.1895 mL
10 mM	0.3095 mL	1.5474 mL	3.0947 mL

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution
2.
请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution
3.
请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution
4.
请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution
5.
请依序添加每种溶剂： 10% EtOH 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution
6.
请依序添加每种溶剂： 10% EtOH 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.74 mM); Clear solution
7.
请依序添加每种溶剂： PBS

Solubility: 2.5 mg/mL (7.74 mM); Clear solution; Need ultrasonic

参考文献	[1]. Hsu HL, et al. Chloramphenicol Induces Autophagy and Inhibits the Hypoxia Inducible Factor-1 Alpha Pathway in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019 Jan 3;20(1):157. [Content Brief] [2]. Yuan ZR, et al. Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells. Cancer Res. 2008 Jun 15;68(12):4875-81. [Content Brief] [3]. Li CH, et al. Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010 Jul;116(1):140-50. [Content Brief] [4]. Turton JA, et al. Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse. Int J Exp Pathol. 2006 Apr;87(2):101-12. [Content Brief] [5]. Bartlett JG. Chloramphenicol. Med Clin North Am. 1982;66(1):91-102. [Content Brief]

参考文献

[1]. Hsu HL, et al. Chloramphenicol Induces Autophagy and Inhibits the Hypoxia Inducible Factor-1 Alpha Pathway in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019 Jan 3;20(1):157. [Content Brief]

[2]. Yuan ZR, et al. Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells. Cancer Res. 2008 Jun 15;68(12):4875-81. [Content Brief]

[3]. Li CH, et al. Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010 Jul;116(1):140-50. [Content Brief]

[4]. Turton JA, et al. Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse. Int J Exp Pathol. 2006 Apr;87(2):101-12. [Content Brief]

[5]. Bartlett JG. Chloramphenicol. Med Clin North Am. 1982;66(1):91-102. [Content Brief]

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大家都在搜

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Chloramphenicol (氯霉素)

相关产品推荐更多 >

五味子酯戊(Schisantherin E)是一天然化合物。

Carbazochrome(AC-17)磺酸钠为抗出血剂。

二氢白屈菜红碱(Dihydrochelerythrine)是从榕树叶片分离出的天然化合物，具抗真菌等活性。

Doxercalciferol-D3是Doxercalciferol的氘化形式，是维生素D2类似物，能作为维生素D受体活化剂。

SU6656 是 Src 家族激酶抑制剂，抑制 Src，Yes，Lyn，Fyn 的 IC50分别为 280，20，130，170 nM。SU6656 可抑制 FAK Y576/577、 Y925、Y861 位点的磷酸化。SU6656 还能抑制p-AKT。

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0 人在求购买到急需产品

Chloramphenicol (Synonyms: 氯霉素)

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