生物活性
Devimistat (CPI-613) is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells[1].
IC50 & Target
mitochondrial metabolism[1]
体外研究
(In Vitro)
Devimistat induces apoptosis of GPM-2 gastric cancer cells. Devimistat targets the altered form of mitochondrial energy metabolism utilized by tumor cells. The change in mitochondrial enzyme activities and cellular redox status induced by devimistat leads to cell death, including apoptosis
分子量
388.59
性状
Solid
Formula
C22H28O2S2
CAS 号
95809-78-2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro:
DMSO : 100 mg/mL (257.34 mM; Need ultrasonic)
配制储备液
浓度溶剂体积质量 1 mg 5 mg 10 mg
1 mM 2.5734 mL 12.8670 mL 25.7341 mL
5 mM 0.5147 mL 2.5734 mL 5.1468 mL
10 mM 0.2573 mL 1.2867 mL 2.5734 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: