生物活性 Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
体外研究(In Vitro) Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1].
体内研究(In Vivo) Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM)[3].
分子量 230.26
性状 Solid
Formula C14H14O3
CAS 号 22204-53-1
中文名称 萘普生;奈普生; 运输条件 Room temperature in continental US; may vary elsewhere.
储存方式 Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month 溶解性数据 In Vitro: DMSO : ≥ 100 mg/mL (434.29 mM)
H2O : 75 mg/mL (325.72 mM; Need ultrasonic and warming)
* "≥" means soluble, but saturation unknown.
配制储备液 浓度溶剂体积质量 1 mg 5 mg 10 mg 1 mM 4.3429 mL 21.7146 mL 43.4292 mL 5 mM 0.8686 mL 4.3429 mL 8.6858 mL 10 mM 0.4343 mL 2.1715 mL 4.3429 mL * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: