生物活性 Tedizolid phosphate (TR-701FA) is a novel oxazolidinone with activity against Gram-positive pathogens.
IC50 & Target Oxazolidinone
体外研究 (In Vitro) Tedizolid phosphate (TR-701FA; 0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP
体内研究 (In Vivo) For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate (TR-701FA) at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1].
分子量 450.32
性状 Solid
Formula C17H16FN6O6P
CAS 号 856867-55-5
中文名称 磷酸特地唑胺
运输条件 Room temperature in continental US; may vary elsewhere.
储存方式 Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month 溶解性数据 In Vitro: DMSO : ≥ 36 mg/mL (79.94 mM)
H2O : 0.1 mg/mL (0.22 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
配制储备液 浓度溶剂体积质量 1 mg 5 mg 10 mg 1 mM 2.2206 mL 11.1032 mL 22.2064 mL 5 mM 0.4441 mL 2.2206 mL 4.4413 mL 10 mM 0.2221 mL 1.1103 mL 2.2206 mL * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: