手机验证
4℃
详见说明
Tirapazamine
充足
杭州昊鑫生物
27314-97-2
50mg
生物活性 | Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells[1][2]. |
||||||||
---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
Tirapazamine (SR259075) is the optimal drug for combination therapy using Pba[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
|
体内研究 (In Vivo) |
Tirapazamine (SR259075) (1mg; intravenously injected; twice at a 24-h interval) shows a synergetic effect to kill tumor cells because TPZ was activated under the hypoxic conditions that originated from the PDT with Pba and laser irradiation[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Clinical Trial |
|
分子量 | 178.15 |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
性状 | Solid |
||||||||||||||||
Formula | C7H6N4O2 |
||||||||||||||||
CAS 号 | |||||||||||||||||
中文名称 | 替拉扎明 |
||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
|
||||||||||||||||
溶解性数据 | In Vitro: DMSO : 62.5 mg/mL (350.83 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。