手机验证
4°C
详见说明
T-5224
充足
杭州昊鑫生物
530141-72-1
100mg
生物活性 | T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription[1][2]. |
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IC50 & Target | c-Fos/activator protein (AP)-1[1] |
体外研究 (In Vitro) |
T-5224 inhibits in-vitro production of the mediators MMP-1, MMP-3, IL-6 and TNF-α by IL-1β-stimulated human synovial SW982 cells with the mean IC50 of about 10 μM[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Administration of T-5224 (300 mg/kg, p.o.) after intraperitoneal injection of LPS impartes appreciable protection against acute elevations in serum levels of TNFα, HMGB1, ALT/AST as well as in liver tissue levels of MIP-1α and MCP-1, and reduces the lethality (27%)[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 | 517.53 |
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性状 | Solid |
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Formula | C29H27NO8 |
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CAS 号 | |||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL (193.23 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百 |
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