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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
CD210 (IL-10R )
- 亚型:
Rat IgG1
- 形态:
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
- 保存条件:
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
- 克隆性:
Monoclonal Antibody
- 标记物:
BIOT
- 适应物种:
Mouse
- 宿主:
Rat
- 应用范围:
FC
- 浓度:
Concentration:0.5 mg/ml
- 靶点:
Clone number:1B1.3A
- 抗体英文名:
CD210 (IL-10R ) Antibody-BIOT;流式抗体
- 抗体名:
CD210 (IL-10R ) Antibody-BIOT;流式抗体
- 规格:
50/500 μg
克隆类型 :Rat Monoclonal Antibody;Clone number:1B1.3A
货 号 :HT1610383
规 格 :50/500 μg ;
亚 型 :
Rat IgG1
浓 度 :
Concentration:0.5 mg/ml
缓 冲 液 :
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
产品描述 :
CD210 is a 90-110 kD IL-10 receptor. It is a class II cytokine receptor expressed on thymocytes, T cells, B cells, NK cells, monocytes and macrophages. Ligand binding of CD210 induces Jak1 and Tyk, resulting in STAT1 and STAT3 activation. IL-10 receptor stimulation results in the inhibition of cytokine production and the costimulation of B cell proliferation and differentiation. The only known ligand for this receptor is IL-10.
适用物种 :
Mouse
应用范围 :
FC
应用说明 :
The amount of the reagent is suggested to be used ≤ 0.25 µg /10^6 cells in 100 µl
保存条件 :
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
标 记 物 :
BIOT(其他荧光标记请咨询我们)
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文献和实验来瓶「红牛」继续干!唐力团队发现 IL-10 可激活终末耗竭 T 细胞,为增强肿瘤免疫治疗提供新思路
(IL-10R)发生反应。在 B16F10 皮下成瘤模型中,作者将识别 gp100 抗原的 PMEL CD8+ T 细胞通过静脉注射转移给小鼠,结果发现 IL-10–Fc 处理可显著增加肿瘤中 CD8+ T 细胞的浸润。在所有 CD8+ TILs 中,IL-10–Fc 可使终末耗竭(terminally exhausted)的 CD8+ T 细胞(TCF-1-TIM-3+)大幅增加,而耗竭性祖(progenitor exhausted)CD8+ T 细胞(TCF-1+TIM-3-)的比例和数量保持
Identifying Regulatory B Cells (B10 Cells) that Produce IL-10 in Mice
Regulatory B cells that produce IL-10 are now recognized as an important component of the immune system. We have identified a rare antigen-specific regulatory B-cell subset with a unique CD1dhi CD5+ CD19hi phenotype in the spleens of wild
, cryopreserving, and thawing human PBMCs; and finally, detecting vaccinia-specific IL-10 and IFNγ secreting lymphocytes, as well as CD8+ IFNγ T cells following in vitro stimulation of PBMCs with vaccinia virus. The methods presented below, although optimized
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